Cargando…

Depletion of PCAT-1 in head and neck cancer cells inhibits tumor growth and induces apoptosis by modulating c-Myc-AKT1-p38 MAPK signalling pathways

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metastasis and aggressive phenotype. Recently, long non-coding RNAs (lncRNAs) have be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sur, Subhayan, Nakanishi, Hiroshi, Steele, Robert, Ray, Ratna B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466688/ https://www.ncbi.nlm.nih.gov/pubmed/30987615 http://dx.doi.org/10.1186/s12885-019-5562-z

Ejemplares similares

Momordicine-I, a Bitter Melon Bioactive Metabolite, Displays Anti-Tumor Activity in Head and Neck Cancer Involving c-Met and Downstream Signaling
por: Sur, Subhayan, et al.
Publicado: (2021)

miRNA-29b Inhibits Prostate Tumor Growth and Induces Apoptosis by Increasing Bim Expression
por: Sur, Subhayan, et al.
Publicado: (2019)

Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial Cells
por: Sur, Subhayan, et al.
Publicado: (2022)

Long noncoding RNA ELDR promotes cell cycle progression in normal oral keratinocytes through induction of a CTCF-FOXM1-AURKA signaling axis
por: Sur, Subhayan, et al.
Publicado: (2022)

Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy
por: Sur, Subhayan, et al.
Publicado: (2020)

Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer
por: Sur, Subhayan, et al.
Publicado: (2021)

Repression of MicroRNA‐30e by Hepatitis C Virus Enhances Fatty Acid Synthesis
por: Sasaki, Reina, et al.
Publicado: (2019)

Knockdown of long non-coding RNA PCAT-1 inhibits myeloma cell growth and drug resistance via p38 and JNK MAPK pathways
por: Shen, Xianjuan, et al.
Publicado: (2019)

Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant Organ
por: Sur, Subhayan, et al.
Publicado: (2021)

The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc()()
por: Prensner, John R., et al.
Publicado: (2014)

Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs
por: Barreto, Rafael, et al.
Publicado: (2016)

Identification of molecular signature of head and neck cancer stem-like cells
por: Shrivastava, Shubham, et al.
Publicado: (2015)

Immunomodulatory role of bitter melon extract in inhibition of head and neck squamous cell carcinoma growth
por: Bhattacharya, Sourav, et al.
Publicado: (2016)

Correction to: Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract
por: Sur, Subhayan, et al.
Publicado: (2019)

Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract
por: Sur, Subhayan, et al.
Publicado: (2019)

Expression Analysis of Long Non-Coding PCAT-1in Breast Cancer
por: Sarrafzadeh, Shaghayegh, et al.
Publicado: (2017)

LncRNA PCAT-1 in gastrointestinal cancers: A meta-analysis
por: Liu, Wanwei, et al.
Publicado: (2018)

LncRNA PCAT1 Interacts with DKC1 to Regulate Proliferation, Invasion and Apoptosis in NSCLC Cells via the VEGF/AKT/Bcl2/Caspase9 Pathway
por: Liu, Shi-Yuan, et al.
Publicado: (2021)

p38 MAPK pathway and its interaction with TRF2 in cisplatin induced chemotherapeutic response in head and neck cancer
por: Roy, Shomereeta, et al.
Publicado: (2018)

Downregulation of Cypher induces apoptosis in cardiomyocytes via Akt/p38 MAPK signaling pathway
por: Xuan, Tianming, et al.
Publicado: (2020)

7‐Epitaxol induces apoptosis in cisplatin‐resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling
por: Yang, Hui‐Ju, et al.
Publicado: (2022)

The Role of lncRNA PCAT6 in Cancers
por: Wang, Siying, et al.
Publicado: (2021)

Therapeutic Targeting of MYC in Head and Neck Squamous Cell Carcinoma
por: Liu, Shuo, et al.
Publicado: (2022)

Sphingosine-1-Phosphate Mediates ICAM-1-Dependent Monocyte Adhesion through p38 MAPK and p42/p44 MAPK-Dependent Akt Activation
por: Lin, Chih-Chung, et al.
Publicado: (2015)

Flavopereirine Inhibits Autophagy via the AKT/p38 MAPK Signaling Pathway in MDA-MB-231 Cells
por: Chen, Ming-Shan, et al.
Publicado: (2020)

Precision drugging of the MAPK pathway in head and neck cancer
por: Ngan, Hoi-Lam, et al.
Publicado: (2022)

Bitter Melon Reduces Head and Neck Squamous Cell Carcinoma Growth by Targeting c-Met Signaling
por: Rajamoorthi, Ananthi, et al.
Publicado: (2013)

PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
por: Xiong, Tiefu, et al.
Publicado: (2019)

Structures of the peptidase-containing ABC transporter PCAT1 under equilibrium and nonequilibrium conditions
por: Kieuvongngam, Virapat, et al.
Publicado: (2022)

Plantamajoside modulates the proliferation, stemness, and apoptosis of lung carcinoma via restraining p38MAPK and AKT phosphorylation
por: Li, Yazhou, et al.
Publicado: (2020)

BCAT1 overexpression regulates proliferation and c-Myc/GLUT1 signaling in head and neck squamous cell carcinoma
por: Wang, Hongming, et al.
Publicado: (2021)

The PCAT3/PCAT9-miR-203-SNAI2 axis functions as a key mediator for prostate tumor growth and progression
por: Tao, Fangfang, et al.
Publicado: (2018)

MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients
por: Reyes-Gibby, Cielito C., et al.
Publicado: (2016)

p38 MAPK and PI3K/AKT Signalling Cascades inParkinson’s Disease
por: Jha, Saurabh Kumar, et al.
Publicado: (2015)

Ang (1–7) Protects Islet Endothelial Cells from Palmitate-Induced Apoptosis by AKT, eNOS, p38 MAPK, and JNK Pathways
por: Yuan, Li, et al.
Publicado: (2014)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

Identification and validation of the role of c-Myc in head and neck squamous cell carcinoma
por: Zhao, Sufeng, et al.
Publicado: (2022)

Identification and Validation of PCAT14 as Prognostic Biomarker in Prostate Cancer()
por: Shukla, Sudhanshu, et al.
Publicado: (2016)

LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex
por: Shang, Zhiqun, et al.
Publicado: (2019)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fj2b9iknripjfpj4kl2elb9ct0