Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols

[Image: see text] Herein we report the manganese-catalyzed C–C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a ((i)P...

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Detalles Bibliográficos
Autores principales: Chakraborty, Subrata, Daw, Prosenjit, Ben David, Yehoshoa, Milstein, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466737/
https://www.ncbi.nlm.nih.gov/pubmed/31007965
http://dx.doi.org/10.1021/acscatal.8b03720
Descripción
Sumario:[Image: see text] Herein we report the manganese-catalyzed C–C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a ((i)Pr-PNP)Mn(H)(CO)(2) pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H(2) in the case of secondary alcohol alkylation) as the sole byproduct.

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