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Tungsten disulfide-based nanocomposites for photothermal therapy

Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS(2)) nanotubes and nanoparticles are among the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and elect...

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Autores principales: Levin, Tzuriel, Sade, Hagit, Binyamini, Rina Ben-Shabbat, Pour, Maayan, Nachman, Iftach, Lellouche, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466784/
https://www.ncbi.nlm.nih.gov/pubmed/31019868
http://dx.doi.org/10.3762/bjnano.10.81
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author Levin, Tzuriel
Sade, Hagit
Binyamini, Rina Ben-Shabbat
Pour, Maayan
Nachman, Iftach
Lellouche, Jean-Paul
author_facet Levin, Tzuriel
Sade, Hagit
Binyamini, Rina Ben-Shabbat
Pour, Maayan
Nachman, Iftach
Lellouche, Jean-Paul
author_sort Levin, Tzuriel
collection PubMed
description Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS(2)) nanotubes and nanoparticles are among the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method for the targeted treatment of cancer, in which a light-responsive material is irradiated with a laser in the near-infrared range. In the current article we present WS(2) nanotubes functionalized with previously reported ceric ammonium nitrate–maghemite (CAN-mag) nanoparticles, used for PTT. Functionalization of the nanotubes with CAN-mag nanoparticles resulted in a magnetic nanocomposite. When tested in vitro with two types of cancer cells, the functionalized nanotubes showed a better PTT activity compared to non-functionalized nanotubes, as well as reduced aggregation and the ability to add a second-step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity.
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spelling pubmed-64667842019-04-24 Tungsten disulfide-based nanocomposites for photothermal therapy Levin, Tzuriel Sade, Hagit Binyamini, Rina Ben-Shabbat Pour, Maayan Nachman, Iftach Lellouche, Jean-Paul Beilstein J Nanotechnol Full Research Paper Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS(2)) nanotubes and nanoparticles are among the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method for the targeted treatment of cancer, in which a light-responsive material is irradiated with a laser in the near-infrared range. In the current article we present WS(2) nanotubes functionalized with previously reported ceric ammonium nitrate–maghemite (CAN-mag) nanoparticles, used for PTT. Functionalization of the nanotubes with CAN-mag nanoparticles resulted in a magnetic nanocomposite. When tested in vitro with two types of cancer cells, the functionalized nanotubes showed a better PTT activity compared to non-functionalized nanotubes, as well as reduced aggregation and the ability to add a second-step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity. Beilstein-Institut 2019-04-02 /pmc/articles/PMC6466784/ /pubmed/31019868 http://dx.doi.org/10.3762/bjnano.10.81 Text en Copyright © 2019, Levin et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjnano/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms)
spellingShingle Full Research Paper
Levin, Tzuriel
Sade, Hagit
Binyamini, Rina Ben-Shabbat
Pour, Maayan
Nachman, Iftach
Lellouche, Jean-Paul
Tungsten disulfide-based nanocomposites for photothermal therapy
title Tungsten disulfide-based nanocomposites for photothermal therapy
title_full Tungsten disulfide-based nanocomposites for photothermal therapy
title_fullStr Tungsten disulfide-based nanocomposites for photothermal therapy
title_full_unstemmed Tungsten disulfide-based nanocomposites for photothermal therapy
title_short Tungsten disulfide-based nanocomposites for photothermal therapy
title_sort tungsten disulfide-based nanocomposites for photothermal therapy
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466784/
https://www.ncbi.nlm.nih.gov/pubmed/31019868
http://dx.doi.org/10.3762/bjnano.10.81
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