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DegNorm: normalization of generalized transcript degradation improves accuracy in RNA-seq analysis
RNA degradation affects RNA-seq quality when profiling transcriptional activities in cells. Here, we show that transcript degradation is both gene- and sample-specific and is a common and significant factor that may bias the results in RNA-seq analysis. Most existing global normalization approaches...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466807/ https://www.ncbi.nlm.nih.gov/pubmed/30992037 http://dx.doi.org/10.1186/s13059-019-1682-7 |