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Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease
BACKGROUND: We believe that, in patients with Parkinson's disease (PD), a forward-directed increase in the subjective vertical position (SV) leads to prolonged worsening of forward flexion of the trunk (FFT) mainly because the body adjusts to the SV. We conducted a study to clarify the relation...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466872/ https://www.ncbi.nlm.nih.gov/pubmed/31061695 http://dx.doi.org/10.1155/2019/1875435 |
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author | Mikami, Kyohei Shiraishi, Makoto Kamo, Tsutomu |
author_facet | Mikami, Kyohei Shiraishi, Makoto Kamo, Tsutomu |
author_sort | Mikami, Kyohei |
collection | PubMed |
description | BACKGROUND: We believe that, in patients with Parkinson's disease (PD), a forward-directed increase in the subjective vertical position (SV) leads to prolonged worsening of forward flexion of the trunk (FFT) mainly because the body adjusts to the SV. We conducted a study to clarify the relation between the SV angle, FFT angle, and various other clinical measures by comparing baseline values against values obtained 1 year later. METHODS: A total of 39 PD patients (mean age, 71.9 ± 10.1 years; disease duration, 7.2 ± 5.4 years; modified Hoehn & Yahr (mH&Y) score, 2.6 ± 0.7) were enrolled. The Unified Parkinson's Disease Rating Scale score, Mini-Mental State Examination (MMSE) score, mH&Y score, FFT angle, SV angle, and levodopa-equivalent dose (LED) were assessed at the time of enrollment (baseline evaluation) and 1 year later. RESULTS: Eighteen patients (46%) complied with the protocol and completed the study. Significant increases were observed in the 1-year SV angle (p=0.02), MMSE score (p=0.008), and LED (p=0.001) compared to baseline values. Correlation was observed between the baseline SV angle and baseline and 1-year FFT angles (r=0.64, p=0.008 and r=0.58, p=0.012, respectively) and between the 1-year SV angle and 1-year FFT angle (r=0.63, p=0.005). CONCLUSION: Our data suggest that the SV contributes to increased FFT. |
format | Online Article Text |
id | pubmed-6466872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64668722019-05-06 Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease Mikami, Kyohei Shiraishi, Makoto Kamo, Tsutomu Parkinsons Dis Research Article BACKGROUND: We believe that, in patients with Parkinson's disease (PD), a forward-directed increase in the subjective vertical position (SV) leads to prolonged worsening of forward flexion of the trunk (FFT) mainly because the body adjusts to the SV. We conducted a study to clarify the relation between the SV angle, FFT angle, and various other clinical measures by comparing baseline values against values obtained 1 year later. METHODS: A total of 39 PD patients (mean age, 71.9 ± 10.1 years; disease duration, 7.2 ± 5.4 years; modified Hoehn & Yahr (mH&Y) score, 2.6 ± 0.7) were enrolled. The Unified Parkinson's Disease Rating Scale score, Mini-Mental State Examination (MMSE) score, mH&Y score, FFT angle, SV angle, and levodopa-equivalent dose (LED) were assessed at the time of enrollment (baseline evaluation) and 1 year later. RESULTS: Eighteen patients (46%) complied with the protocol and completed the study. Significant increases were observed in the 1-year SV angle (p=0.02), MMSE score (p=0.008), and LED (p=0.001) compared to baseline values. Correlation was observed between the baseline SV angle and baseline and 1-year FFT angles (r=0.64, p=0.008 and r=0.58, p=0.012, respectively) and between the 1-year SV angle and 1-year FFT angle (r=0.63, p=0.005). CONCLUSION: Our data suggest that the SV contributes to increased FFT. Hindawi 2019-04-02 /pmc/articles/PMC6466872/ /pubmed/31061695 http://dx.doi.org/10.1155/2019/1875435 Text en Copyright © 2019 Kyohei Mikami et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mikami, Kyohei Shiraishi, Makoto Kamo, Tsutomu Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease |
title | Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease |
title_full | Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease |
title_fullStr | Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease |
title_full_unstemmed | Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease |
title_short | Subjective Vertical Position Allows Prediction of Postural Deterioration in Patients with Parkinson's Disease |
title_sort | subjective vertical position allows prediction of postural deterioration in patients with parkinson's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466872/ https://www.ncbi.nlm.nih.gov/pubmed/31061695 http://dx.doi.org/10.1155/2019/1875435 |
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