Current understanding of the role and regulation of miRNAs in Burkitt lymphoma

Since its discovery in 1958, Burkitt lymphoma (BL) has been extensively studied and has become a model for tumorigenesis, but its pathogenesis has not been completely explained and understood yet. The aim of this review was to summarize the current knowledge about BL and, in particular, to discuss t...

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Detalles Bibliográficos
Autores principales: Videtta, Alessandro Davide, Malagnino, Valeria, De Falco, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467348/
https://www.ncbi.nlm.nih.gov/pubmed/31360092
http://dx.doi.org/10.2147/BLCTT.S129618
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author Videtta, Alessandro Davide
Malagnino, Valeria
De Falco, Giulia
author_facet Videtta, Alessandro Davide
Malagnino, Valeria
De Falco, Giulia
author_sort Videtta, Alessandro Davide
collection PubMed
description Since its discovery in 1958, Burkitt lymphoma (BL) has been extensively studied and has become a model for tumorigenesis, but its pathogenesis has not been completely explained and understood yet. The aim of this review was to summarize the current knowledge about BL and, in particular, to discuss the role of miRNAs in its pathogenesis and their possible use as diagnostic and prognostic indicators. The impact of viral-encoded miRNAs is also discussed, with the Epstein–Barr infection being almost invariably detected in the endemic variant of this tumor.
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spelling pubmed-64673482019-07-29 Current understanding of the role and regulation of miRNAs in Burkitt lymphoma Videtta, Alessandro Davide Malagnino, Valeria De Falco, Giulia Blood Lymphat Cancer Review Since its discovery in 1958, Burkitt lymphoma (BL) has been extensively studied and has become a model for tumorigenesis, but its pathogenesis has not been completely explained and understood yet. The aim of this review was to summarize the current knowledge about BL and, in particular, to discuss the role of miRNAs in its pathogenesis and their possible use as diagnostic and prognostic indicators. The impact of viral-encoded miRNAs is also discussed, with the Epstein–Barr infection being almost invariably detected in the endemic variant of this tumor. Dove Medical Press 2018-05-11 /pmc/articles/PMC6467348/ /pubmed/31360092 http://dx.doi.org/10.2147/BLCTT.S129618 Text en © 2018 Videtta et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Videtta, Alessandro Davide
Malagnino, Valeria
De Falco, Giulia
Current understanding of the role and regulation of miRNAs in Burkitt lymphoma
title Current understanding of the role and regulation of miRNAs in Burkitt lymphoma
title_full Current understanding of the role and regulation of miRNAs in Burkitt lymphoma
title_fullStr Current understanding of the role and regulation of miRNAs in Burkitt lymphoma
title_full_unstemmed Current understanding of the role and regulation of miRNAs in Burkitt lymphoma
title_short Current understanding of the role and regulation of miRNAs in Burkitt lymphoma
title_sort current understanding of the role and regulation of mirnas in burkitt lymphoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467348/
https://www.ncbi.nlm.nih.gov/pubmed/31360092
http://dx.doi.org/10.2147/BLCTT.S129618
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