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Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts

The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle. Viral replication is then necessary for regeneration of a diverse mutant swarm. It is now underst...

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Detalles Bibliográficos
Autores principales:	Warmbrod, K. Lane, Patterson, Edward I., Kautz, Tiffany F., Stanton, Adam, Rockx-Brouwer, Dedeke, Kalveram, Birte K., Khanipov, Kamil, Thangamani, Saravanan, Fofanov, Yuriy, Forrester, Naomi L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467425/ https://www.ncbi.nlm.nih.gov/pubmed/30947291 http://dx.doi.org/10.1371/journal.ppat.1007610

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