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DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells
Class switch recombination (CSR) requires activation-induced cytidine deaminase (AID) to trigger DNA double strand breaks (DSBs) at the immunoglobulin heavy chain (IGH) in B cells. Joining of AID-dependent DSBs within IGH facilitate CSR and effective humoral immunity, but ligation to DSBs in non-IGH...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467426/ https://www.ncbi.nlm.nih.gov/pubmed/30946744 http://dx.doi.org/10.1371/journal.pgen.1008101 |