Cargando…
Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer
BACKGROUND: Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck cancer. METHODS: Patients diagnos...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467749/ https://www.ncbi.nlm.nih.gov/pubmed/30554450 http://dx.doi.org/10.1002/hed.25563 |
_version_ | 1783411304428470272 |
---|---|
author | Egyud, Matthew Sridhar, Praveen Devaiah, Anand Yamada, Emiko Saunders, Stefanie Ståhlberg, Anders Filges, Stefan Krzyzanowski, Paul M. Kalatskaya, Irina Jiao, Wei Stein, Lincoln D. Jalisi, Scharukh Godfrey, Tony E. |
author_facet | Egyud, Matthew Sridhar, Praveen Devaiah, Anand Yamada, Emiko Saunders, Stefanie Ståhlberg, Anders Filges, Stefan Krzyzanowski, Paul M. Kalatskaya, Irina Jiao, Wei Stein, Lincoln D. Jalisi, Scharukh Godfrey, Tony E. |
author_sort | Egyud, Matthew |
collection | PubMed |
description | BACKGROUND: Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck cancer. METHODS: Patients diagnosed with head and neck squamous cell carcinoma were recruited into the study protocol. Tumors were sequenced to identify patient‐specific mutations. Mutations were then identified in plasma circulating tumor DNA from pre‐treatment blood samples and longitudinally during standard follow‐up. Circulating tumor DNA status during follow‐up was correlated to disease recurrence. RESULTS: Samples were taken from eight patients. Tumor mutations were verified in seven patients. Baseline circulating tumor DNA was positive in six patients. Recurrence occurred in four patients, two of whom had detectable circulating tumor DNA prior to recurrence. CONCLUSION: Circulating tumor DNA is a potential tool for disease and recurrence monitoring following curative therapy in head and neck cancer, allowing for better prognostication, and/or modification of treatment strategies. |
format | Online Article Text |
id | pubmed-6467749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64677492019-05-21 Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer Egyud, Matthew Sridhar, Praveen Devaiah, Anand Yamada, Emiko Saunders, Stefanie Ståhlberg, Anders Filges, Stefan Krzyzanowski, Paul M. Kalatskaya, Irina Jiao, Wei Stein, Lincoln D. Jalisi, Scharukh Godfrey, Tony E. Head Neck Original Articles BACKGROUND: Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck cancer. METHODS: Patients diagnosed with head and neck squamous cell carcinoma were recruited into the study protocol. Tumors were sequenced to identify patient‐specific mutations. Mutations were then identified in plasma circulating tumor DNA from pre‐treatment blood samples and longitudinally during standard follow‐up. Circulating tumor DNA status during follow‐up was correlated to disease recurrence. RESULTS: Samples were taken from eight patients. Tumor mutations were verified in seven patients. Baseline circulating tumor DNA was positive in six patients. Recurrence occurred in four patients, two of whom had detectable circulating tumor DNA prior to recurrence. CONCLUSION: Circulating tumor DNA is a potential tool for disease and recurrence monitoring following curative therapy in head and neck cancer, allowing for better prognostication, and/or modification of treatment strategies. John Wiley & Sons, Inc. 2018-12-15 2019-05 /pmc/articles/PMC6467749/ /pubmed/30554450 http://dx.doi.org/10.1002/hed.25563 Text en © 2018 The Authors. Head & Neck published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Egyud, Matthew Sridhar, Praveen Devaiah, Anand Yamada, Emiko Saunders, Stefanie Ståhlberg, Anders Filges, Stefan Krzyzanowski, Paul M. Kalatskaya, Irina Jiao, Wei Stein, Lincoln D. Jalisi, Scharukh Godfrey, Tony E. Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer |
title | Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer |
title_full | Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer |
title_fullStr | Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer |
title_full_unstemmed | Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer |
title_short | Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer |
title_sort | plasma circulating tumor dna as a potential tool for disease monitoring in head and neck cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467749/ https://www.ncbi.nlm.nih.gov/pubmed/30554450 http://dx.doi.org/10.1002/hed.25563 |
work_keys_str_mv | AT egyudmatthew plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT sridharpraveen plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT devaiahanand plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT yamadaemiko plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT saundersstefanie plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT stahlberganders plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT filgesstefan plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT krzyzanowskipaulm plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT kalatskayairina plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT jiaowei plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT steinlincolnd plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT jalisischarukh plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer AT godfreytonye plasmacirculatingtumordnaasapotentialtoolfordiseasemonitoringinheadandneckcancer |