Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma (GBM) do not represent a clonal entity defined by distinct functional prope...

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Detalles Bibliográficos
Autores principales: Dirkse, Anne, Golebiewska, Anna, Buder, Thomas, Nazarov, Petr V., Muller, Arnaud, Poovathingal, Suresh, Brons, Nicolaas H. C., Leite, Sonia, Sauvageot, Nicolas, Sarkisjan, Dzjemma, Seyfrid, Mathieu, Fritah, Sabrina, Stieber, Daniel, Michelucci, Alessandro, Hertel, Frank, Herold-Mende, Christel, Azuaje, Francisco, Skupin, Alexander, Bjerkvig, Rolf, Deutsch, Andreas, Voss-Böhme, Anja, Niclou, Simone P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467886/
https://www.ncbi.nlm.nih.gov/pubmed/30992437
http://dx.doi.org/10.1038/s41467-019-09853-z

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