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Microfluidic multipoles theory and applications
Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for “open-space” biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the la...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467910/ https://www.ncbi.nlm.nih.gov/pubmed/30992450 http://dx.doi.org/10.1038/s41467-019-09740-7 |
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author | Goyette, Pierre-Alexandre Boulais, Étienne Normandeau, Frédéric Laberge, Gabriel Juncker, David Gervais, Thomas |
author_facet | Goyette, Pierre-Alexandre Boulais, Étienne Normandeau, Frédéric Laberge, Gabriel Juncker, David Gervais, Thomas |
author_sort | Goyette, Pierre-Alexandre |
collection | PubMed |
description | Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for “open-space” biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. The models are validated experimentally with a library of 3D printed devices and found in excellent agreement. Following a theory-guided design approach, we further ideate and fabricate two classes of spatiotemporally reconfigurable multipolar devices that are used for processing surfaces with time-varying reagent streams, and to realize a multistep automated immunoassay. Overall, the results set the foundations for exploring, developing, and applying open-space microfluidic multipoles. |
format | Online Article Text |
id | pubmed-6467910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64679102019-04-18 Microfluidic multipoles theory and applications Goyette, Pierre-Alexandre Boulais, Étienne Normandeau, Frédéric Laberge, Gabriel Juncker, David Gervais, Thomas Nat Commun Article Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for “open-space” biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. The models are validated experimentally with a library of 3D printed devices and found in excellent agreement. Following a theory-guided design approach, we further ideate and fabricate two classes of spatiotemporally reconfigurable multipolar devices that are used for processing surfaces with time-varying reagent streams, and to realize a multistep automated immunoassay. Overall, the results set the foundations for exploring, developing, and applying open-space microfluidic multipoles. Nature Publishing Group UK 2019-04-16 /pmc/articles/PMC6467910/ /pubmed/30992450 http://dx.doi.org/10.1038/s41467-019-09740-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Goyette, Pierre-Alexandre Boulais, Étienne Normandeau, Frédéric Laberge, Gabriel Juncker, David Gervais, Thomas Microfluidic multipoles theory and applications |
title | Microfluidic multipoles theory and applications |
title_full | Microfluidic multipoles theory and applications |
title_fullStr | Microfluidic multipoles theory and applications |
title_full_unstemmed | Microfluidic multipoles theory and applications |
title_short | Microfluidic multipoles theory and applications |
title_sort | microfluidic multipoles theory and applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467910/ https://www.ncbi.nlm.nih.gov/pubmed/30992450 http://dx.doi.org/10.1038/s41467-019-09740-7 |
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