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Gender-Specific Associations Between Saliva Microbiota and Body Size
OBJECTIVE: The human intestinal microbiota likely play an important role in the development of overweight and obesity. However, the associations between saliva microbiota and body mass index (BMI) have been sparsely studied. The aim of this study was to identify the associations between saliva micro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467948/ https://www.ncbi.nlm.nih.gov/pubmed/31024514 http://dx.doi.org/10.3389/fmicb.2019.00767 |
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author | Raju, Sajan C. Lagström, Sonja Ellonen, Pekka de Vos, Willem M. Eriksson, Johan G. Weiderpass, Elisabete Rounge, Trine B. |
author_facet | Raju, Sajan C. Lagström, Sonja Ellonen, Pekka de Vos, Willem M. Eriksson, Johan G. Weiderpass, Elisabete Rounge, Trine B. |
author_sort | Raju, Sajan C. |
collection | PubMed |
description | OBJECTIVE: The human intestinal microbiota likely play an important role in the development of overweight and obesity. However, the associations between saliva microbiota and body mass index (BMI) have been sparsely studied. The aim of this study was to identify the associations between saliva microbiota and body size in Finnish children. METHODS: The saliva microbiota of 900 Finnish children, aged 11–14 years with measured height and weight, was characterized using 16S rRNA (V3–V4) sequencing. RESULTS: The core saliva microbiota consisted of 14 genera that were present in more than 95% of the Finnish children. The saliva microbiota profiles were gender-specific with higher alpha-diversity in boys than girls and significant differences between the genders in community composition and abundances. Alpha-diversity differed between normal weight and overweight girls and between normal weight and obese boys. The composition was dissimilar between normal weight and obese girls, but not in boys. The relative abundance profiles differed according to body size. Decrease in commensal saliva bacteria were observed in all the body sizes when compared to normal weight children. Notably, the relative abundance of bacteria related to, Veillonella, Prevotella, Selenomonas, and Streptococcus was reduced in obese children. CONCLUSION: Saliva microbiota diversity and composition were significantly associated with body size and gender in Finnish children. Body size–specific saliva microbiota profiles open new avenues for studying the potential roles of microbiota in weight development and management. |
format | Online Article Text |
id | pubmed-6467948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64679482019-04-25 Gender-Specific Associations Between Saliva Microbiota and Body Size Raju, Sajan C. Lagström, Sonja Ellonen, Pekka de Vos, Willem M. Eriksson, Johan G. Weiderpass, Elisabete Rounge, Trine B. Front Microbiol Microbiology OBJECTIVE: The human intestinal microbiota likely play an important role in the development of overweight and obesity. However, the associations between saliva microbiota and body mass index (BMI) have been sparsely studied. The aim of this study was to identify the associations between saliva microbiota and body size in Finnish children. METHODS: The saliva microbiota of 900 Finnish children, aged 11–14 years with measured height and weight, was characterized using 16S rRNA (V3–V4) sequencing. RESULTS: The core saliva microbiota consisted of 14 genera that were present in more than 95% of the Finnish children. The saliva microbiota profiles were gender-specific with higher alpha-diversity in boys than girls and significant differences between the genders in community composition and abundances. Alpha-diversity differed between normal weight and overweight girls and between normal weight and obese boys. The composition was dissimilar between normal weight and obese girls, but not in boys. The relative abundance profiles differed according to body size. Decrease in commensal saliva bacteria were observed in all the body sizes when compared to normal weight children. Notably, the relative abundance of bacteria related to, Veillonella, Prevotella, Selenomonas, and Streptococcus was reduced in obese children. CONCLUSION: Saliva microbiota diversity and composition were significantly associated with body size and gender in Finnish children. Body size–specific saliva microbiota profiles open new avenues for studying the potential roles of microbiota in weight development and management. Frontiers Media S.A. 2019-04-10 /pmc/articles/PMC6467948/ /pubmed/31024514 http://dx.doi.org/10.3389/fmicb.2019.00767 Text en Copyright © 2019 Raju, Lagström, Ellonen, de Vos, Eriksson, Weiderpass and Rounge. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Raju, Sajan C. Lagström, Sonja Ellonen, Pekka de Vos, Willem M. Eriksson, Johan G. Weiderpass, Elisabete Rounge, Trine B. Gender-Specific Associations Between Saliva Microbiota and Body Size |
title | Gender-Specific Associations Between Saliva Microbiota and Body Size |
title_full | Gender-Specific Associations Between Saliva Microbiota and Body Size |
title_fullStr | Gender-Specific Associations Between Saliva Microbiota and Body Size |
title_full_unstemmed | Gender-Specific Associations Between Saliva Microbiota and Body Size |
title_short | Gender-Specific Associations Between Saliva Microbiota and Body Size |
title_sort | gender-specific associations between saliva microbiota and body size |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467948/ https://www.ncbi.nlm.nih.gov/pubmed/31024514 http://dx.doi.org/10.3389/fmicb.2019.00767 |
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