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Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia
Acute Eosinophilic Pneumonia (AEP) is a potentially fatal cause of hypoxemic respiratory failure characterized by fever, diffuse bilateral pulmonary infiltrates, and pulmonary eosinophilia. Shown to be associated with a number of environmental exposures and lifestyle choices, AEP has a good prognosi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467954/ https://www.ncbi.nlm.nih.gov/pubmed/31024915 http://dx.doi.org/10.3389/fmed.2019.00065 |
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author | Dougherty, Sean C. Ghaus, Sophia Debesa, Orlando |
author_facet | Dougherty, Sean C. Ghaus, Sophia Debesa, Orlando |
author_sort | Dougherty, Sean C. |
collection | PubMed |
description | Acute Eosinophilic Pneumonia (AEP) is a potentially fatal cause of hypoxemic respiratory failure characterized by fever, diffuse bilateral pulmonary infiltrates, and pulmonary eosinophilia. Shown to be associated with a number of environmental exposures and lifestyle choices, AEP has a good prognosis when diagnosed early and treated with corticosteroids. In this clinical case report, we detail the presentation, evaluation, diagnosis, and management of a 40-year old male who presented to the emergency department with dyspnea, chills, and diaphoresis. He had a history of pulmonary embolism 8 years prior but was otherwise healthy, though he had re-started smoking cigarettes a week prior to presentation. Initial chest CT scan revealed widespread mixed groundglass and solid airspace opacities; over the next 12 hours, he rapidly decompensated and after not responding to other invasive mechanical ventilation, was emergently cannulated for veno-venous extracorporeal membrane oxygenation (V-V ECMO). Bronchoalveolar lavage later revealed pulmonary eosinophilia, and after an infectious workup was negative, a diagnosis of AEP was reached and the patient was started on corticosteroids. To our knowledge, this is one of few published cases of AEP requiring V-V ECMO for clinical stabilization, highlighting the utility of this treatment modality in severe disease. |
format | Online Article Text |
id | pubmed-6467954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64679542019-04-25 Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia Dougherty, Sean C. Ghaus, Sophia Debesa, Orlando Front Med (Lausanne) Medicine Acute Eosinophilic Pneumonia (AEP) is a potentially fatal cause of hypoxemic respiratory failure characterized by fever, diffuse bilateral pulmonary infiltrates, and pulmonary eosinophilia. Shown to be associated with a number of environmental exposures and lifestyle choices, AEP has a good prognosis when diagnosed early and treated with corticosteroids. In this clinical case report, we detail the presentation, evaluation, diagnosis, and management of a 40-year old male who presented to the emergency department with dyspnea, chills, and diaphoresis. He had a history of pulmonary embolism 8 years prior but was otherwise healthy, though he had re-started smoking cigarettes a week prior to presentation. Initial chest CT scan revealed widespread mixed groundglass and solid airspace opacities; over the next 12 hours, he rapidly decompensated and after not responding to other invasive mechanical ventilation, was emergently cannulated for veno-venous extracorporeal membrane oxygenation (V-V ECMO). Bronchoalveolar lavage later revealed pulmonary eosinophilia, and after an infectious workup was negative, a diagnosis of AEP was reached and the patient was started on corticosteroids. To our knowledge, this is one of few published cases of AEP requiring V-V ECMO for clinical stabilization, highlighting the utility of this treatment modality in severe disease. Frontiers Media S.A. 2019-04-10 /pmc/articles/PMC6467954/ /pubmed/31024915 http://dx.doi.org/10.3389/fmed.2019.00065 Text en Copyright © 2019 Dougherty, Ghaus and Debesa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Dougherty, Sean C. Ghaus, Sophia Debesa, Orlando Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia |
title | Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia |
title_full | Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia |
title_fullStr | Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia |
title_full_unstemmed | Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia |
title_short | Extracorporeal Membrane Oxygenation in Severe Acute Eosinophilic Pneumonia |
title_sort | extracorporeal membrane oxygenation in severe acute eosinophilic pneumonia |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467954/ https://www.ncbi.nlm.nih.gov/pubmed/31024915 http://dx.doi.org/10.3389/fmed.2019.00065 |
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