Structure-based Design of JOC-x, a Conjugatable Tumor Tight Junction Opener to Enhance Cancer Therapy

Disorganized intercellular junctions are critical for maintaining the integrity of solid epithelial tumors and prevent the infiltration of oncological therapies into the bulk of the malignancy. We have developed small, recombinant proteins which bind a critical junction protein, desmoglein 2, trigge...

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Detalles Bibliográficos
Autores principales: Pitner, Ragan, Kim, Jiho, Davis-Bergthold, Jenn, Turner, Cheri, Vassal-Stermann, Emilie, Wang, Hongjie, Adams, Jaclyn, Carter, Lauren, Ahlgren, Jeffrey A., Fender, Pascal, Lieber, André, Carter, Darrick, Gray, Sean A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467980/
https://www.ncbi.nlm.nih.gov/pubmed/30992466
http://dx.doi.org/10.1038/s41598-019-42229-3

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