The dual role of innate immunity during influenza

One of the distinguishing features of the 1918 pandemic is the occurrence of massive, potentially detrimental, activation of the innate immune system in critically ill patients. Whether this reflects an intrinsic capacity of the virus to induce an exaggerated inflammatory responses or its remarkable...

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Detalles Bibliográficos
Autores principales: Biondo, Carmelo, Lentini, Germana, Beninati, Concetta, Teti, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2019
Materias:
Special Edition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468094/
https://www.ncbi.nlm.nih.gov/pubmed/30987709
http://dx.doi.org/10.1016/j.bj.2018.12.009
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author Biondo, Carmelo
Lentini, Germana
Beninati, Concetta
Teti, Giuseppe
author_facet Biondo, Carmelo
Lentini, Germana
Beninati, Concetta
Teti, Giuseppe
author_sort Biondo, Carmelo
collection PubMed
description One of the distinguishing features of the 1918 pandemic is the occurrence of massive, potentially detrimental, activation of the innate immune system in critically ill patients. Whether this reflects an intrinsic capacity of the virus to induce an exaggerated inflammatory responses or its remarkable ability to reproduce in vivo is still open to debate. Tremendous progress has recently been made in our understanding of innate immune responses to influenza infection and it is now time to translate this knowledge into therapeutic strategies, particularly in view of the possible occurrence of future outbreaks caused by virulent strains.
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spelling pubmed-64680942019-04-24 The dual role of innate immunity during influenza Biondo, Carmelo Lentini, Germana Beninati, Concetta Teti, Giuseppe Biomed J Special Edition One of the distinguishing features of the 1918 pandemic is the occurrence of massive, potentially detrimental, activation of the innate immune system in critically ill patients. Whether this reflects an intrinsic capacity of the virus to induce an exaggerated inflammatory responses or its remarkable ability to reproduce in vivo is still open to debate. Tremendous progress has recently been made in our understanding of innate immune responses to influenza infection and it is now time to translate this knowledge into therapeutic strategies, particularly in view of the possible occurrence of future outbreaks caused by virulent strains. Chang Gung University 2019-02 2019-03-20 /pmc/articles/PMC6468094/ /pubmed/30987709 http://dx.doi.org/10.1016/j.bj.2018.12.009 Text en © 2019 Chang Gung University. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Special Edition
Biondo, Carmelo
Lentini, Germana
Beninati, Concetta
Teti, Giuseppe
The dual role of innate immunity during influenza
title The dual role of innate immunity during influenza
title_full The dual role of innate immunity during influenza
title_fullStr The dual role of innate immunity during influenza
title_full_unstemmed The dual role of innate immunity during influenza
title_short The dual role of innate immunity during influenza
title_sort dual role of innate immunity during influenza
topic Special Edition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468094/
https://www.ncbi.nlm.nih.gov/pubmed/30987709
http://dx.doi.org/10.1016/j.bj.2018.12.009
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