Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats

Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this persistent effect, and microglial inhibition at the time of adult reincision blocks the enhanced hyperalgesia. Here, we ph...

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Detalles Bibliográficos
Autores principales: Moriarty, Orla, Tu, YuShan, Sengar, Ameet S., Salter, Michael W., Beggs, Simon, Walker, Suellen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468109/
https://www.ncbi.nlm.nih.gov/pubmed/30796159
http://dx.doi.org/10.1523/JNEUROSCI.1786-18.2019

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