ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells

Werner syndrome (WS) is a cancer-prone disease caused by deficiency of Werner protein (WRN). WRN maintains genome integrity by promoting replication-fork stability after various forms of replication stress. Under mild replication stress, WS cells show impaired ATR-mediated CHK1 activation. However,...

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Detalles Bibliográficos
Autores principales: Marabitti, Veronica, Lillo, Giorgia, Malacaria, Eva, Palermo, Valentina, Sanchez, Massimo, Pichierri, Pietro, Franchitto, Annapaola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468170/
https://www.ncbi.nlm.nih.gov/pubmed/30657978
http://dx.doi.org/10.1093/nar/gkz025

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