Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters were used to treat the cancer cells. Methods: The influence of CuO content on the morphology, drug delivering ability, physicochemical properties and cytotoxicity was investigated. Results: The microcrystalline str...

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Detalles Bibliográficos
Autores principales: Mabrouk, Mostafa, Kenawy, Sayed Hamed, El-bassyouni, Gehan El-Tabie, Ibrahim Soliman, Ahmed Abd El-Fattah, Aly Hamzawy, Esmat Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468231/
https://www.ncbi.nlm.nih.gov/pubmed/31011564
http://dx.doi.org/10.15171/apb.2019.013
Descripción
Sumario:Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters were used to treat the cancer cells. Methods: The influence of CuO content on the morphology, drug delivering ability, physicochemical properties and cytotoxicity was investigated. Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to (5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycycline hyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusion of CuO and Dox didn’t show any remarkable changes on the physicochemical properties of the CuO-doped calcium silicate nanoparticles. Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicity against the tested cell lines compared to the CuO-free sample. CuO-doped materials displayed significant anticancer effect; this sheds light on its implication in the treatment of cancer.

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