Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols

A highly selective Cu(II)‐catalyzed cross‐dehydrogenative ortho‐aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp(2))−C(sp(3)) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A ra...

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Detalles Bibliográficos
Autores principales: Yu, Congjun, Patureau, Frederic W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468272/
https://www.ncbi.nlm.nih.gov/pubmed/29931717
http://dx.doi.org/10.1002/anie.201804829
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author Yu, Congjun
Patureau, Frederic W.
author_facet Yu, Congjun
Patureau, Frederic W.
author_sort Yu, Congjun
collection PubMed
description A highly selective Cu(II)‐catalyzed cross‐dehydrogenative ortho‐aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp(2))−C(sp(3)) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed.
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spelling pubmed-64682722019-04-24 Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols Yu, Congjun Patureau, Frederic W. Angew Chem Int Ed Engl Communications A highly selective Cu(II)‐catalyzed cross‐dehydrogenative ortho‐aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp(2))−C(sp(3)) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed. John Wiley and Sons Inc. 2018-08-01 2018-09-03 /pmc/articles/PMC6468272/ /pubmed/29931717 http://dx.doi.org/10.1002/anie.201804829 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Yu, Congjun
Patureau, Frederic W.
Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols
title Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols
title_full Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols
title_fullStr Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols
title_full_unstemmed Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols
title_short Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols
title_sort cu‐catalyzed cross‐dehydrogenative ortho‐aminomethylation of phenols
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468272/
https://www.ncbi.nlm.nih.gov/pubmed/29931717
http://dx.doi.org/10.1002/anie.201804829
work_keys_str_mv AT yucongjun cucatalyzedcrossdehydrogenativeorthoaminomethylationofphenols
AT patureaufredericw cucatalyzedcrossdehydrogenativeorthoaminomethylationofphenols

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