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Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors
The proper tissue-specific regulation of gene expression is essential for development and homeostasis in metazoans. However, the illegitimate expression of normally tissue-restricted genes—like testis- or placenta-specific genes—is frequently observed in tumors; this promotes transformation, but als...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468300/ https://www.ncbi.nlm.nih.gov/pubmed/30753595 http://dx.doi.org/10.1093/nar/gkz080 |