Submolecular dissection reveals strong and specific binding of polyamide–pyridostatin conjugates to human telomere interface

To modulate biological functions, G-quadruplexes in genome are often non-specifically targeted by small molecules. Here, specificity is increased by targeting both G-quadruplex and its flanking duplex DNA in a naturally occurring dsDNA–ssDNA telomere interface using polyamide (PA) and pyridostatin (...

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Detalles Bibliográficos
Autores principales: Mandal, Shankar, Kawamoto, Yusuke, Yue, Zhizhou, Hashiya, Kaori, Cui, Yunxi, Bando, Toshikazu, Pandey, Shankar, Hoque, Mohammed Enamul, Hossain, Mohammad Akter, Sugiyama, Hiroshi, Mao, Hanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468309/
https://www.ncbi.nlm.nih.gov/pubmed/30820532
http://dx.doi.org/10.1093/nar/gkz135

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