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Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction

The soluble urokinase-type plasminogen activator receptor (suPAR) is a new marker for immune activation and inflammation and may provide diagnostic value on top of established biomarkers in patients with suspected acute myocardial infarction (AMI). Here, we evaluate the diagnostic potential of suPAR...

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Autores principales: Sörensen, Nils A., Dönmez, Günay, Neumann, Johannes T., Nikorowitsch, Julius, Rübsamen, Nicole, Blankenberg, Stefan, Westermann, Dirk, Zeller, Tanja, Karakas, Mahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468350/
https://www.ncbi.nlm.nih.gov/pubmed/30889909
http://dx.doi.org/10.3390/biom9030108
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author Sörensen, Nils A.
Dönmez, Günay
Neumann, Johannes T.
Nikorowitsch, Julius
Rübsamen, Nicole
Blankenberg, Stefan
Westermann, Dirk
Zeller, Tanja
Karakas, Mahir
author_facet Sörensen, Nils A.
Dönmez, Günay
Neumann, Johannes T.
Nikorowitsch, Julius
Rübsamen, Nicole
Blankenberg, Stefan
Westermann, Dirk
Zeller, Tanja
Karakas, Mahir
author_sort Sörensen, Nils A.
collection PubMed
description The soluble urokinase-type plasminogen activator receptor (suPAR) is a new marker for immune activation and inflammation and may provide diagnostic value on top of established biomarkers in patients with suspected acute myocardial infarction (AMI). Here, we evaluate the diagnostic potential of suPAR levels on top of high-sensitivity troponin I (hs-TnI) in a cohort of patients with suspected AMI. A total of 1220 patients presenting to the emergency department with suspected AMI were included, of whom 245 were diagnosed with AMI. Median suPAR levels at admission were elevated in subjects with AMI compared to non-AMI (3.8 ng/mL vs. 3.3 ng/mL, p = 0.001). In C-statistics, the area under the curve (AUC) regarding the diagnosis of AMI was low (0.57 at an optimized cut-off of 3.7 ng/mL). Moreover, baseline suPAR levels on top of troponin values at admission and hour 1 reduced the number of patients who were correctly ruled-out as non-AMI, and who were correctly ruled-in as AMI. Our study shows that circulating levels of suPAR on top of high-sensitivity troponin I do not improve the early diagnosis of AMI.
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spelling pubmed-64683502019-04-24 Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction Sörensen, Nils A. Dönmez, Günay Neumann, Johannes T. Nikorowitsch, Julius Rübsamen, Nicole Blankenberg, Stefan Westermann, Dirk Zeller, Tanja Karakas, Mahir Biomolecules Article The soluble urokinase-type plasminogen activator receptor (suPAR) is a new marker for immune activation and inflammation and may provide diagnostic value on top of established biomarkers in patients with suspected acute myocardial infarction (AMI). Here, we evaluate the diagnostic potential of suPAR levels on top of high-sensitivity troponin I (hs-TnI) in a cohort of patients with suspected AMI. A total of 1220 patients presenting to the emergency department with suspected AMI were included, of whom 245 were diagnosed with AMI. Median suPAR levels at admission were elevated in subjects with AMI compared to non-AMI (3.8 ng/mL vs. 3.3 ng/mL, p = 0.001). In C-statistics, the area under the curve (AUC) regarding the diagnosis of AMI was low (0.57 at an optimized cut-off of 3.7 ng/mL). Moreover, baseline suPAR levels on top of troponin values at admission and hour 1 reduced the number of patients who were correctly ruled-out as non-AMI, and who were correctly ruled-in as AMI. Our study shows that circulating levels of suPAR on top of high-sensitivity troponin I do not improve the early diagnosis of AMI. MDPI 2019-03-18 /pmc/articles/PMC6468350/ /pubmed/30889909 http://dx.doi.org/10.3390/biom9030108 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sörensen, Nils A.
Dönmez, Günay
Neumann, Johannes T.
Nikorowitsch, Julius
Rübsamen, Nicole
Blankenberg, Stefan
Westermann, Dirk
Zeller, Tanja
Karakas, Mahir
Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction
title Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction
title_full Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction
title_fullStr Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction
title_full_unstemmed Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction
title_short Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction
title_sort diagnostic value of soluble urokinase-type plasminogen activator receptor in addition to high-sensitivity troponin i in early diagnosis of acute myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468350/
https://www.ncbi.nlm.nih.gov/pubmed/30889909
http://dx.doi.org/10.3390/biom9030108
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