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EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology

Epithelial-to-mesenchymal transition (EMT) and its reverse process MET naturally occur during development and in tissue repair in vertebrates. EMT is also recognized as the crucial event by which cancer cells acquire an invasive phenotype through the activation of specific transcription factors and...

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Autores principales: Colella, Barbara, Faienza, Fiorella, Di Bartolomeo, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468412/
https://www.ncbi.nlm.nih.gov/pubmed/30845654
http://dx.doi.org/10.3390/cancers11030312
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author Colella, Barbara
Faienza, Fiorella
Di Bartolomeo, Sabrina
author_facet Colella, Barbara
Faienza, Fiorella
Di Bartolomeo, Sabrina
author_sort Colella, Barbara
collection PubMed
description Epithelial-to-mesenchymal transition (EMT) and its reverse process MET naturally occur during development and in tissue repair in vertebrates. EMT is also recognized as the crucial event by which cancer cells acquire an invasive phenotype through the activation of specific transcription factors and signalling pathways. Even though glial cells have a mesenchymal phenotype, an EMT-like process tends to exacerbate it during gliomagenesis and progression to more aggressive stages of the disease. Autophagy is an evolutionary conserved degradative process that cells use in order to maintain a proper homeostasis, and defects in autophagy have been associated to several pathologies including cancer. Besides modulating cell resistance or sensitivity to therapy, autophagy also affects the migration and invasion capabilities of tumor cells. Despite this evidence, few papers are present in literature about the involvement of autophagy in EMT-like processes in glioblastoma (GBM) so far. This review summarizes the current understanding of the interplay between autophagy and EMT in cancer, with special regard to GBM model. As the invasive behaviour is a hallmark of GBM aggressiveness, defining a new link between autophagy and EMT can open a novel scenario for targeting these processes in future therapeutical approaches.
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spelling pubmed-64684122019-04-24 EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology Colella, Barbara Faienza, Fiorella Di Bartolomeo, Sabrina Cancers (Basel) Review Epithelial-to-mesenchymal transition (EMT) and its reverse process MET naturally occur during development and in tissue repair in vertebrates. EMT is also recognized as the crucial event by which cancer cells acquire an invasive phenotype through the activation of specific transcription factors and signalling pathways. Even though glial cells have a mesenchymal phenotype, an EMT-like process tends to exacerbate it during gliomagenesis and progression to more aggressive stages of the disease. Autophagy is an evolutionary conserved degradative process that cells use in order to maintain a proper homeostasis, and defects in autophagy have been associated to several pathologies including cancer. Besides modulating cell resistance or sensitivity to therapy, autophagy also affects the migration and invasion capabilities of tumor cells. Despite this evidence, few papers are present in literature about the involvement of autophagy in EMT-like processes in glioblastoma (GBM) so far. This review summarizes the current understanding of the interplay between autophagy and EMT in cancer, with special regard to GBM model. As the invasive behaviour is a hallmark of GBM aggressiveness, defining a new link between autophagy and EMT can open a novel scenario for targeting these processes in future therapeutical approaches. MDPI 2019-03-06 /pmc/articles/PMC6468412/ /pubmed/30845654 http://dx.doi.org/10.3390/cancers11030312 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Colella, Barbara
Faienza, Fiorella
Di Bartolomeo, Sabrina
EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology
title EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology
title_full EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology
title_fullStr EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology
title_full_unstemmed EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology
title_short EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology
title_sort emt regulation by autophagy: a new perspective in glioblastoma biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468412/
https://www.ncbi.nlm.nih.gov/pubmed/30845654
http://dx.doi.org/10.3390/cancers11030312
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