miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4

miRNAs are closely associated with tumor genesis and development. The present study investigated the role of the expression of miRNA-766 in the survival of patients with colon cancer and the underlying molecular mechanisms. Reverse transcription-quantitative polymerase chain reaction analysis and mi...

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Autores principales: Chen, Weirong, Cai, Gaoyang, Liao, Ziqun, Lin, Kaihuang, Li, Guangrong, Li, Yanchong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468453/
https://www.ncbi.nlm.nih.gov/pubmed/31007746
http://dx.doi.org/10.3892/etm.2019.7436
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author Chen, Weirong
Cai, Gaoyang
Liao, Ziqun
Lin, Kaihuang
Li, Guangrong
Li, Yanchong
author_facet Chen, Weirong
Cai, Gaoyang
Liao, Ziqun
Lin, Kaihuang
Li, Guangrong
Li, Yanchong
author_sort Chen, Weirong
collection PubMed
description miRNAs are closely associated with tumor genesis and development. The present study investigated the role of the expression of miRNA-766 in the survival of patients with colon cancer and the underlying molecular mechanisms. Reverse transcription-quantitative polymerase chain reaction analysis and microarray analysis were used to analyze the expression of miRNA-766. The results revealed that the expression of miRNA-766 was decreased in patients with colon cancer. The overall survival and disease-free survival rates of patients with colon cancer with a high expression of miRNA-766 were prolonged, compared with those with a low expression of miRNA-766. The overexpression of miRNA-766 reduced cell growth and induced apoptosis in colon cancer cells through suppression of the MDM4/p53 pathway. By contrast, the downregulation of miRNA-766 promoted cell growth and reduced apoptosis in colon cancer cells through activation of the MDM4/p53 pathway. The promotion of MDM4 attenuated the anticancer effect of miRNA-766 in colon cancer cells. These results demonstrated that miRNA-766 induced cell apoptosis in human colon cancer through MDM4/p53.
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spelling pubmed-64684532019-04-19 miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4 Chen, Weirong Cai, Gaoyang Liao, Ziqun Lin, Kaihuang Li, Guangrong Li, Yanchong Exp Ther Med Articles miRNAs are closely associated with tumor genesis and development. The present study investigated the role of the expression of miRNA-766 in the survival of patients with colon cancer and the underlying molecular mechanisms. Reverse transcription-quantitative polymerase chain reaction analysis and microarray analysis were used to analyze the expression of miRNA-766. The results revealed that the expression of miRNA-766 was decreased in patients with colon cancer. The overall survival and disease-free survival rates of patients with colon cancer with a high expression of miRNA-766 were prolonged, compared with those with a low expression of miRNA-766. The overexpression of miRNA-766 reduced cell growth and induced apoptosis in colon cancer cells through suppression of the MDM4/p53 pathway. By contrast, the downregulation of miRNA-766 promoted cell growth and reduced apoptosis in colon cancer cells through activation of the MDM4/p53 pathway. The promotion of MDM4 attenuated the anticancer effect of miRNA-766 in colon cancer cells. These results demonstrated that miRNA-766 induced cell apoptosis in human colon cancer through MDM4/p53. D.A. Spandidos 2019-05 2019-03-26 /pmc/articles/PMC6468453/ /pubmed/31007746 http://dx.doi.org/10.3892/etm.2019.7436 Text en Copyright: © Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Chen, Weirong
Cai, Gaoyang
Liao, Ziqun
Lin, Kaihuang
Li, Guangrong
Li, Yanchong
miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4
title miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4
title_full miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4
title_fullStr miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4
title_full_unstemmed miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4
title_short miRNA-766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4
title_sort mirna-766 induces apoptosis of human colon cancer cells through the p53/bax signaling pathway by mdm4
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468453/
https://www.ncbi.nlm.nih.gov/pubmed/31007746
http://dx.doi.org/10.3892/etm.2019.7436
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