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The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure

The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in myocardial and skeleta...

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Detalles Bibliográficos
Autores principales: Shi, Mingshu, Ellingsen, Øyvind, Bathen, Tone Frost, Høydal, Morten A., Stølen, Tomas, Esmaeili, Morteza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468534/
https://www.ncbi.nlm.nih.gov/pubmed/30893827
http://dx.doi.org/10.3390/metabo9030053
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author Shi, Mingshu
Ellingsen, Øyvind
Bathen, Tone Frost
Høydal, Morten A.
Stølen, Tomas
Esmaeili, Morteza
author_facet Shi, Mingshu
Ellingsen, Øyvind
Bathen, Tone Frost
Høydal, Morten A.
Stølen, Tomas
Esmaeili, Morteza
author_sort Shi, Mingshu
collection PubMed
description The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in myocardial and skeletal muscle in HF and exercise training using MRS, and thus to identify targets for clinical MRS in vivo. After surgically establishing HF in rats, we randomized the rats to exercise training programs of different intensities. After the final training session, rats were sacrificed and tissues from the myocardial and skeletal muscle were extracted. Magnetic resonance spectra were acquired from these extracts, and principal component and metabolic enrichment analysis were used to assess the differences in metabolic profiles. The results indicated that HF affected myocardial metabolism by changing multiple metabolites, whereas it had a limited effect on skeletal muscle metabolism. Moreover, exercise training mainly altered the metabolite distribution in skeletal muscle, indicating regulation of metabolic pathways of taurine and hypotaurine metabolism and carnitine synthesis.
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spelling pubmed-64685342019-04-22 The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure Shi, Mingshu Ellingsen, Øyvind Bathen, Tone Frost Høydal, Morten A. Stølen, Tomas Esmaeili, Morteza Metabolites Article The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in myocardial and skeletal muscle in HF and exercise training using MRS, and thus to identify targets for clinical MRS in vivo. After surgically establishing HF in rats, we randomized the rats to exercise training programs of different intensities. After the final training session, rats were sacrificed and tissues from the myocardial and skeletal muscle were extracted. Magnetic resonance spectra were acquired from these extracts, and principal component and metabolic enrichment analysis were used to assess the differences in metabolic profiles. The results indicated that HF affected myocardial metabolism by changing multiple metabolites, whereas it had a limited effect on skeletal muscle metabolism. Moreover, exercise training mainly altered the metabolite distribution in skeletal muscle, indicating regulation of metabolic pathways of taurine and hypotaurine metabolism and carnitine synthesis. MDPI 2019-03-19 /pmc/articles/PMC6468534/ /pubmed/30893827 http://dx.doi.org/10.3390/metabo9030053 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Mingshu
Ellingsen, Øyvind
Bathen, Tone Frost
Høydal, Morten A.
Stølen, Tomas
Esmaeili, Morteza
The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure
title The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure
title_full The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure
title_fullStr The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure
title_full_unstemmed The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure
title_short The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure
title_sort effect of exercise training on myocardial and skeletal muscle metabolism by mr spectroscopy in rats with heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468534/
https://www.ncbi.nlm.nih.gov/pubmed/30893827
http://dx.doi.org/10.3390/metabo9030053
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