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Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study

Background: Pheochromocytomas (PHEO) are tumors arising from chromaffin cells from the adrenal medulla, having the ability to produce, metabolize and secrete catecholamines. The overproduction of catecholamines leads by many mechanisms to the impairment in the left ventricle (LV) function, however,...

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Autores principales: Kvasnička, Jan, Zelinka, Tomáš, Petrák, Ondřej, Rosa, Ján, Štrauch, Branislav, Krátká, Zuzana, Indra, Tomáš, Markvartová, Alice, Widimský, Jiří, Holaj, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468537/
https://www.ncbi.nlm.nih.gov/pubmed/30845735
http://dx.doi.org/10.3390/cancers11030318
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author Kvasnička, Jan
Zelinka, Tomáš
Petrák, Ondřej
Rosa, Ján
Štrauch, Branislav
Krátká, Zuzana
Indra, Tomáš
Markvartová, Alice
Widimský, Jiří
Holaj, Robert
author_facet Kvasnička, Jan
Zelinka, Tomáš
Petrák, Ondřej
Rosa, Ján
Štrauch, Branislav
Krátká, Zuzana
Indra, Tomáš
Markvartová, Alice
Widimský, Jiří
Holaj, Robert
author_sort Kvasnička, Jan
collection PubMed
description Background: Pheochromocytomas (PHEO) are tumors arising from chromaffin cells from the adrenal medulla, having the ability to produce, metabolize and secrete catecholamines. The overproduction of catecholamines leads by many mechanisms to the impairment in the left ventricle (LV) function, however, endocardial measurement of systolic function did not find any differences between patients with PHEO and essential hypertension (EH). The aim of the study was to investigate whether global longitudinal strain (GLS) derived from speckle-tracking echocardiography can detect catecholamine-induced subclinical impairments in systolic function. Methods: We analyzed 17 patients (10 females and seven males) with PHEO and 18 patients (nine females and nine males) with EH. The groups did not differ in age or in 24-h blood pressure values. Results: The patients with PHEO did not differ in echocardiographic parameters including LV ejection fraction compared to the EH patients (0.69 ± 0.04 vs. 0.71 ± 0.05; NS), nevertheless, in spackle-tracking analysis, the patients with PHEO displayed significantly lower GLS than the EH patients (−14.8 ± 1.5 vs. −17.8 ± 1.7; p < 0.001). Conclusions: Patients with PHEO have a lower magnitude of GLS than the patients with EH, suggesting that catecholamines induce a subclinical decline in LV systolic function.
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spelling pubmed-64685372019-04-24 Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study Kvasnička, Jan Zelinka, Tomáš Petrák, Ondřej Rosa, Ján Štrauch, Branislav Krátká, Zuzana Indra, Tomáš Markvartová, Alice Widimský, Jiří Holaj, Robert Cancers (Basel) Article Background: Pheochromocytomas (PHEO) are tumors arising from chromaffin cells from the adrenal medulla, having the ability to produce, metabolize and secrete catecholamines. The overproduction of catecholamines leads by many mechanisms to the impairment in the left ventricle (LV) function, however, endocardial measurement of systolic function did not find any differences between patients with PHEO and essential hypertension (EH). The aim of the study was to investigate whether global longitudinal strain (GLS) derived from speckle-tracking echocardiography can detect catecholamine-induced subclinical impairments in systolic function. Methods: We analyzed 17 patients (10 females and seven males) with PHEO and 18 patients (nine females and nine males) with EH. The groups did not differ in age or in 24-h blood pressure values. Results: The patients with PHEO did not differ in echocardiographic parameters including LV ejection fraction compared to the EH patients (0.69 ± 0.04 vs. 0.71 ± 0.05; NS), nevertheless, in spackle-tracking analysis, the patients with PHEO displayed significantly lower GLS than the EH patients (−14.8 ± 1.5 vs. −17.8 ± 1.7; p < 0.001). Conclusions: Patients with PHEO have a lower magnitude of GLS than the patients with EH, suggesting that catecholamines induce a subclinical decline in LV systolic function. MDPI 2019-03-06 /pmc/articles/PMC6468537/ /pubmed/30845735 http://dx.doi.org/10.3390/cancers11030318 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kvasnička, Jan
Zelinka, Tomáš
Petrák, Ondřej
Rosa, Ján
Štrauch, Branislav
Krátká, Zuzana
Indra, Tomáš
Markvartová, Alice
Widimský, Jiří
Holaj, Robert
Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study
title Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study
title_full Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study
title_fullStr Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study
title_full_unstemmed Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study
title_short Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study
title_sort catecholamines induce left ventricular subclinical systolic dysfunction: a speckle-tracking echocardiography study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468537/
https://www.ncbi.nlm.nih.gov/pubmed/30845735
http://dx.doi.org/10.3390/cancers11030318
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