Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression

Neuropathic pain is a worldwide health concern with poor treatment outcomes. Accumulating evidence suggests that histone hypoacetylation is involved in development and maintenance of neuropathic pain. Thus, many natural and synthetic histone deacetylase (HDACs) inhibitors were tested and exhibited a...

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Detalles Bibliográficos
Autores principales: Ouyang, Bihan, Chen, Dan, Hou, Xinran, Wang, Tongxuan, Wang, Jian, Zou, Wangyuan, Song, Zongbin, Huang, Changsheng, Guo, Qulian, Weng, Yingqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468568/
https://www.ncbi.nlm.nih.gov/pubmed/31024248
http://dx.doi.org/10.3389/fnins.2019.00346

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