Multiple CH/π Interactions Maintain the Binding of Aflatoxin B(1) in the Active Cavity of Human Cytochrome P450 1A2

Human cytochrome P450 1A2 (CYP1A2) is one of the key CYPs that activate aflatoxin B(1) (AFB(1)), a notorious mycotoxin, into carcinogenic exo-8,9-epoxides (AFBO) in the liver. Although the structure of CYP1A2 is available, the mechanism of CYP1A2-specific binding to AFB(1) has not been fully clarifi...

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Detalles Bibliográficos
Autores principales: Wu, Jun, Zhu, Sisi, Wu, Yunbo, Jiang, Tianqing, Wang, Lingling, Jiang, Jun, Wen, Jikai, Deng, Yiqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468651/
https://www.ncbi.nlm.nih.gov/pubmed/30871064
http://dx.doi.org/10.3390/toxins11030158

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