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Targeting FER Kinase Inhibits Melanoma Growth and Metastasis
Melanoma is one of the most aggressive types of tumors and exhibits high metastatic potential. Fes-related (FER) kinase is a non-receptor tyrosine kinase that has been implicated in growth and metastasis of various epithelial tumors. In this study, we have examined the role that FER kinase plays in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468679/ https://www.ncbi.nlm.nih.gov/pubmed/30909648 http://dx.doi.org/10.3390/cancers11030419 |
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author | Ivanova, Iordanka A. Arulanantham, Shinthujah Barr, Kevin Cepeda, Mario Parkins, Katie M. Hamilton, Amanda M. Johnston, Danielle Penuela, Silvia Hess, David A. Ronald, John A. Dagnino, Lina |
author_facet | Ivanova, Iordanka A. Arulanantham, Shinthujah Barr, Kevin Cepeda, Mario Parkins, Katie M. Hamilton, Amanda M. Johnston, Danielle Penuela, Silvia Hess, David A. Ronald, John A. Dagnino, Lina |
author_sort | Ivanova, Iordanka A. |
collection | PubMed |
description | Melanoma is one of the most aggressive types of tumors and exhibits high metastatic potential. Fes-related (FER) kinase is a non-receptor tyrosine kinase that has been implicated in growth and metastasis of various epithelial tumors. In this study, we have examined the role that FER kinase plays in melanoma at the molecular level. FER-depleted melanoma cells exhibit impaired Wnt/β-catenin pathway activity, as well as multiple proteomic changes, which include decreased abundance of L1-cell adhesion molecule (L1-CAM). Consistent with the pro-metastatic functions of these pathways, we demonstrate that depletion of FER kinase decreases melanoma growth and formation of distant metastases in a xenograft model. These findings indicate that FER is an important positive regulator of melanoma metastasis and a potential target for innovative therapies. |
format | Online Article Text |
id | pubmed-6468679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64686792019-04-24 Targeting FER Kinase Inhibits Melanoma Growth and Metastasis Ivanova, Iordanka A. Arulanantham, Shinthujah Barr, Kevin Cepeda, Mario Parkins, Katie M. Hamilton, Amanda M. Johnston, Danielle Penuela, Silvia Hess, David A. Ronald, John A. Dagnino, Lina Cancers (Basel) Article Melanoma is one of the most aggressive types of tumors and exhibits high metastatic potential. Fes-related (FER) kinase is a non-receptor tyrosine kinase that has been implicated in growth and metastasis of various epithelial tumors. In this study, we have examined the role that FER kinase plays in melanoma at the molecular level. FER-depleted melanoma cells exhibit impaired Wnt/β-catenin pathway activity, as well as multiple proteomic changes, which include decreased abundance of L1-cell adhesion molecule (L1-CAM). Consistent with the pro-metastatic functions of these pathways, we demonstrate that depletion of FER kinase decreases melanoma growth and formation of distant metastases in a xenograft model. These findings indicate that FER is an important positive regulator of melanoma metastasis and a potential target for innovative therapies. MDPI 2019-03-24 /pmc/articles/PMC6468679/ /pubmed/30909648 http://dx.doi.org/10.3390/cancers11030419 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ivanova, Iordanka A. Arulanantham, Shinthujah Barr, Kevin Cepeda, Mario Parkins, Katie M. Hamilton, Amanda M. Johnston, Danielle Penuela, Silvia Hess, David A. Ronald, John A. Dagnino, Lina Targeting FER Kinase Inhibits Melanoma Growth and Metastasis |
title | Targeting FER Kinase Inhibits Melanoma Growth and Metastasis |
title_full | Targeting FER Kinase Inhibits Melanoma Growth and Metastasis |
title_fullStr | Targeting FER Kinase Inhibits Melanoma Growth and Metastasis |
title_full_unstemmed | Targeting FER Kinase Inhibits Melanoma Growth and Metastasis |
title_short | Targeting FER Kinase Inhibits Melanoma Growth and Metastasis |
title_sort | targeting fer kinase inhibits melanoma growth and metastasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468679/ https://www.ncbi.nlm.nih.gov/pubmed/30909648 http://dx.doi.org/10.3390/cancers11030419 |
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