Detection of Metabolic Changes Induced via Drug Treatments in Live Cancer Cells and Tissue Using Raman Imaging Microscopy

Isocitrate dehydrogenase 1 (IDH1) mutations in gliomas, fibrosarcoma, and other cancers leads to a novel metabolite, D-2-hydroxyglutarate, which is proposed to cause tumorigenesis. The production of this metabolite also causes vulnerabilities in cellular metabolism, such as lowering NADPH levels. To...

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Detalles Bibliográficos
Autores principales: Larion, Mioara, Dowdy, Tyrone, Ruiz-Rodado, Victor, Meyer, Matthew W., Song, Hua, Zhang, Wei, Davis, Dionne, Gilbert, Mark R., Lita, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468689/
https://www.ncbi.nlm.nih.gov/pubmed/30597885
http://dx.doi.org/10.3390/bios9010005

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