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Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects
Particulate matter (PM) exposure and metabolic syndrome (MetSyn) are both significant global health burdens. PM exposure has been implicated in the pathogenesis of MetSyn and cardiopulmonary diseases. Individuals with pre-existing MetSyn may be more susceptible to the detrimental effects of PM expos...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468691/ https://www.ncbi.nlm.nih.gov/pubmed/30704059 http://dx.doi.org/10.3390/toxics7010006 |
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author | Clementi, Emily A. Talusan, Angela Vaidyanathan, Sandhya Veerappan, Arul Mikhail, Mena Ostrofsky, Dean Crowley, George Kim, James S. Kwon, Sophia Nolan, Anna |
author_facet | Clementi, Emily A. Talusan, Angela Vaidyanathan, Sandhya Veerappan, Arul Mikhail, Mena Ostrofsky, Dean Crowley, George Kim, James S. Kwon, Sophia Nolan, Anna |
author_sort | Clementi, Emily A. |
collection | PubMed |
description | Particulate matter (PM) exposure and metabolic syndrome (MetSyn) are both significant global health burdens. PM exposure has been implicated in the pathogenesis of MetSyn and cardiopulmonary diseases. Individuals with pre-existing MetSyn may be more susceptible to the detrimental effects of PM exposure. Our aim was to provide a narrative review of MetSyn/PM-induced systemic inflammation in cardiopulmonary disease, with a focus on prior studies of the World Trade Center (WTC)-exposed Fire Department of New York (FDNY). We included studies (1) published within the last 16-years; (2) described the epidemiology of MetSyn, obstructive airway disease (OAD), and vascular disease in PM-exposed individuals; (3) detailed the known mechanisms of PM-induced inflammation, MetSyn and cardiopulmonary disease; and (4) focused on the effects of PM exposure in WTC-exposed FDNY firefighters. Several investigations support that inhalation of PM elicits pulmonary and systemic inflammation resulting in MetSyn and cardiopulmonary disease. Furthermore, individuals with these preexisting conditions are more sensitive to PM exposure-related inflammation, which can exacerbate their conditions and increase their risk for hospitalization and chronic disease. Mechanistic research is required to elucidate biologically plausible therapeutic targets of MetSyn- and PM-induced cardiopulmonary disease. |
format | Online Article Text |
id | pubmed-6468691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64686912019-04-22 Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects Clementi, Emily A. Talusan, Angela Vaidyanathan, Sandhya Veerappan, Arul Mikhail, Mena Ostrofsky, Dean Crowley, George Kim, James S. Kwon, Sophia Nolan, Anna Toxics Review Particulate matter (PM) exposure and metabolic syndrome (MetSyn) are both significant global health burdens. PM exposure has been implicated in the pathogenesis of MetSyn and cardiopulmonary diseases. Individuals with pre-existing MetSyn may be more susceptible to the detrimental effects of PM exposure. Our aim was to provide a narrative review of MetSyn/PM-induced systemic inflammation in cardiopulmonary disease, with a focus on prior studies of the World Trade Center (WTC)-exposed Fire Department of New York (FDNY). We included studies (1) published within the last 16-years; (2) described the epidemiology of MetSyn, obstructive airway disease (OAD), and vascular disease in PM-exposed individuals; (3) detailed the known mechanisms of PM-induced inflammation, MetSyn and cardiopulmonary disease; and (4) focused on the effects of PM exposure in WTC-exposed FDNY firefighters. Several investigations support that inhalation of PM elicits pulmonary and systemic inflammation resulting in MetSyn and cardiopulmonary disease. Furthermore, individuals with these preexisting conditions are more sensitive to PM exposure-related inflammation, which can exacerbate their conditions and increase their risk for hospitalization and chronic disease. Mechanistic research is required to elucidate biologically plausible therapeutic targets of MetSyn- and PM-induced cardiopulmonary disease. MDPI 2019-01-30 /pmc/articles/PMC6468691/ /pubmed/30704059 http://dx.doi.org/10.3390/toxics7010006 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Clementi, Emily A. Talusan, Angela Vaidyanathan, Sandhya Veerappan, Arul Mikhail, Mena Ostrofsky, Dean Crowley, George Kim, James S. Kwon, Sophia Nolan, Anna Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects |
title | Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects |
title_full | Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects |
title_fullStr | Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects |
title_full_unstemmed | Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects |
title_short | Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects |
title_sort | metabolic syndrome and air pollution: a narrative review of their cardiopulmonary effects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468691/ https://www.ncbi.nlm.nih.gov/pubmed/30704059 http://dx.doi.org/10.3390/toxics7010006 |
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