(18)F-FDG PET/CT Findings in Cytomegalovirus Colitis

We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An (18)F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 week...

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Autores principales: Kjaer, Anna Sophie L., Ribberholt, Iben, Thomsen, Kim, Ibsen, Per H., Markova, Elena, Graff, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468765/
https://www.ncbi.nlm.nih.gov/pubmed/30587768
http://dx.doi.org/10.3390/diagnostics9010003
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author Kjaer, Anna Sophie L.
Ribberholt, Iben
Thomsen, Kim
Ibsen, Per H.
Markova, Elena
Graff, Jesper
author_facet Kjaer, Anna Sophie L.
Ribberholt, Iben
Thomsen, Kim
Ibsen, Per H.
Markova, Elena
Graff, Jesper
author_sort Kjaer, Anna Sophie L.
collection PubMed
description We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An (18)F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological (18)F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive (18)F-FDG PET/CT scan of the colon can be due to CMV colitis.
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spelling pubmed-64687652019-04-19 (18)F-FDG PET/CT Findings in Cytomegalovirus Colitis Kjaer, Anna Sophie L. Ribberholt, Iben Thomsen, Kim Ibsen, Per H. Markova, Elena Graff, Jesper Diagnostics (Basel) Interesting Images We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An (18)F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological (18)F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive (18)F-FDG PET/CT scan of the colon can be due to CMV colitis. MDPI 2018-12-26 /pmc/articles/PMC6468765/ /pubmed/30587768 http://dx.doi.org/10.3390/diagnostics9010003 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Kjaer, Anna Sophie L.
Ribberholt, Iben
Thomsen, Kim
Ibsen, Per H.
Markova, Elena
Graff, Jesper
(18)F-FDG PET/CT Findings in Cytomegalovirus Colitis
title (18)F-FDG PET/CT Findings in Cytomegalovirus Colitis
title_full (18)F-FDG PET/CT Findings in Cytomegalovirus Colitis
title_fullStr (18)F-FDG PET/CT Findings in Cytomegalovirus Colitis
title_full_unstemmed (18)F-FDG PET/CT Findings in Cytomegalovirus Colitis
title_short (18)F-FDG PET/CT Findings in Cytomegalovirus Colitis
title_sort (18)f-fdg pet/ct findings in cytomegalovirus colitis
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468765/
https://www.ncbi.nlm.nih.gov/pubmed/30587768
http://dx.doi.org/10.3390/diagnostics9010003
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