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Function and Evolution of Nematode RNAi Pathways

Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting...

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Autores principales: Almeida, Miguel Vasconcelos, Andrade-Navarro, Miguel A., Ketting, René F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468775/
https://www.ncbi.nlm.nih.gov/pubmed/30650636
http://dx.doi.org/10.3390/ncrna5010008
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author Almeida, Miguel Vasconcelos
Andrade-Navarro, Miguel A.
Ketting, René F.
author_facet Almeida, Miguel Vasconcelos
Andrade-Navarro, Miguel A.
Ketting, René F.
author_sort Almeida, Miguel Vasconcelos
collection PubMed
description Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting RNA (piRNA) pathways were implicated in silencing selfish genetic elements in a variety of organisms. Nematodes have several incredibly specialized, rapidly evolving endogenous RNAi-like pathways serving such purposes. Here, we review recent research regarding the RNAi-like pathways of Caenorhabditis elegans as well as those of other nematodes, to provide an evolutionary perspective. We argue that multiple nematode RNAi-like pathways share piRNA-like properties and together form a broad nematode toolkit that allows for silencing of foreign genetic elements.
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spelling pubmed-64687752019-04-19 Function and Evolution of Nematode RNAi Pathways Almeida, Miguel Vasconcelos Andrade-Navarro, Miguel A. Ketting, René F. Noncoding RNA Review Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting RNA (piRNA) pathways were implicated in silencing selfish genetic elements in a variety of organisms. Nematodes have several incredibly specialized, rapidly evolving endogenous RNAi-like pathways serving such purposes. Here, we review recent research regarding the RNAi-like pathways of Caenorhabditis elegans as well as those of other nematodes, to provide an evolutionary perspective. We argue that multiple nematode RNAi-like pathways share piRNA-like properties and together form a broad nematode toolkit that allows for silencing of foreign genetic elements. MDPI 2019-01-15 /pmc/articles/PMC6468775/ /pubmed/30650636 http://dx.doi.org/10.3390/ncrna5010008 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Almeida, Miguel Vasconcelos
Andrade-Navarro, Miguel A.
Ketting, René F.
Function and Evolution of Nematode RNAi Pathways
title Function and Evolution of Nematode RNAi Pathways
title_full Function and Evolution of Nematode RNAi Pathways
title_fullStr Function and Evolution of Nematode RNAi Pathways
title_full_unstemmed Function and Evolution of Nematode RNAi Pathways
title_short Function and Evolution of Nematode RNAi Pathways
title_sort function and evolution of nematode rnai pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468775/
https://www.ncbi.nlm.nih.gov/pubmed/30650636
http://dx.doi.org/10.3390/ncrna5010008
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