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Function and Evolution of Nematode RNAi Pathways
Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468775/ https://www.ncbi.nlm.nih.gov/pubmed/30650636 http://dx.doi.org/10.3390/ncrna5010008 |
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author | Almeida, Miguel Vasconcelos Andrade-Navarro, Miguel A. Ketting, René F. |
author_facet | Almeida, Miguel Vasconcelos Andrade-Navarro, Miguel A. Ketting, René F. |
author_sort | Almeida, Miguel Vasconcelos |
collection | PubMed |
description | Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting RNA (piRNA) pathways were implicated in silencing selfish genetic elements in a variety of organisms. Nematodes have several incredibly specialized, rapidly evolving endogenous RNAi-like pathways serving such purposes. Here, we review recent research regarding the RNAi-like pathways of Caenorhabditis elegans as well as those of other nematodes, to provide an evolutionary perspective. We argue that multiple nematode RNAi-like pathways share piRNA-like properties and together form a broad nematode toolkit that allows for silencing of foreign genetic elements. |
format | Online Article Text |
id | pubmed-6468775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64687752019-04-19 Function and Evolution of Nematode RNAi Pathways Almeida, Miguel Vasconcelos Andrade-Navarro, Miguel A. Ketting, René F. Noncoding RNA Review Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting RNA (piRNA) pathways were implicated in silencing selfish genetic elements in a variety of organisms. Nematodes have several incredibly specialized, rapidly evolving endogenous RNAi-like pathways serving such purposes. Here, we review recent research regarding the RNAi-like pathways of Caenorhabditis elegans as well as those of other nematodes, to provide an evolutionary perspective. We argue that multiple nematode RNAi-like pathways share piRNA-like properties and together form a broad nematode toolkit that allows for silencing of foreign genetic elements. MDPI 2019-01-15 /pmc/articles/PMC6468775/ /pubmed/30650636 http://dx.doi.org/10.3390/ncrna5010008 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Almeida, Miguel Vasconcelos Andrade-Navarro, Miguel A. Ketting, René F. Function and Evolution of Nematode RNAi Pathways |
title | Function and Evolution of Nematode RNAi Pathways |
title_full | Function and Evolution of Nematode RNAi Pathways |
title_fullStr | Function and Evolution of Nematode RNAi Pathways |
title_full_unstemmed | Function and Evolution of Nematode RNAi Pathways |
title_short | Function and Evolution of Nematode RNAi Pathways |
title_sort | function and evolution of nematode rnai pathways |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468775/ https://www.ncbi.nlm.nih.gov/pubmed/30650636 http://dx.doi.org/10.3390/ncrna5010008 |
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