Cargando…

Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses

Emodin is the main component of traditional Chinese medicines including rhubarb, Polygonum multiflorum, and Polygonum cuspidatum. It has confirmed hepatotoxicity and may be the main causative agent of liver damage associated with the above-mentioned traditional Chinese medicines. However, current re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Longfei, Liu, Yuling, Fu, Sai, Qu, Changhai, Li, Hui, Ni, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468815/ https://www.ncbi.nlm.nih.gov/pubmed/30897821 http://dx.doi.org/10.3390/cells8030263

Ejemplares similares

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
por: Zhang, Miao, et al.
Publicado: (2018)

UPLC-Q-TOF/MS-Based Metabolomics Approach to Reveal the Hepatotoxicity of Emodin and Detoxification of Dihydromyricetin
por: Gao, Jian, et al.
Publicado: (2021)

Proteomics Unravels Emodin Causes Liver Oxidative Damage Elicited by Mitochondrial Dysfunction
por: Zhang, Yinhuan, et al.
Publicado: (2020)

Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase-dependent pathway
por: Dong, Xiaoxv, et al.
Publicado: (2018)

Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I
por: Ling, Sunbin, et al.
Publicado: (2017)

Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response
por: You, Longtai, et al.
Publicado: (2019)

Emodin enhances osteogenesis and inhibits adipogenesis
por: Yang, Feng, et al.
Publicado: (2014)

Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway
por: Chen, Peng, et al.
Publicado: (2021)

Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ERα Inhibition
por: Huang, Pao-Hsuan, et al.
Publicado: (2013)

Cell Metabolomics Reveals the Potential Mechanism of Aloe Emodin and Emodin Inhibiting Breast Cancer Metastasis
por: Cheng, Guorong, et al.
Publicado: (2022)

Forced Degradation Studies of Aloe Emodin and Emodin by HPTLC
por: Narayanan, Sindhu, et al.
Publicado: (2015)

The Comparison of the Efficiency of Emodin and Aloe-Emodin in Photodynamic Therapy
por: Nowak-Perlak, Martyna, et al.
Publicado: (2022)

Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro
por: LIU, DIAN-LEI, et al.
Publicado: (2011)

Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia
por: Li, Rong-Rong, et al.
Publicado: (2019)

Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses
por: Song, Jiayu, et al.
Publicado: (2022)

iTRAQ Quantitative Proteomic Analysis of Different Expressed Proteins and Signal Pathways in Bakuchiol-Induced Hepatotoxicity
por: Gao, Shu-Yan, et al.
Publicado: (2022)

Alterations of Amino Acid Level in Depressed Rat Brain
por: Yang, Pei, et al.
Publicado: (2014)

Correction: iTRAQ-based quantitative proteomic analysis for identification of biomarkers associated with emodin against severe acute pancreatitis in rats
por: Xiang, Hong, et al.
Publicado: (2019)

Emodin Inhibits EBV Reactivation and Represses NPC Tumorigenesis
por: Wu, Chung-Chun, et al.
Publicado: (2019)

Emodin-Induced Oxidative Inhibition of Mitochondrial Function Assists BiP/IRE1α/CHOP Signaling-Mediated ER-Related Apoptosis
por: Qiu, Li-zhen, et al.
Publicado: (2021)

Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol
por: Wu, Jian-Hong, et al.
Publicado: (2021)

Anticancer potential of emodin
por: Hsu, Shu-Chun, et al.
Publicado: (2012)

Hepatotoxic potential of asarones: in vitro evaluation of hepatotoxicity and quantitative determination in herbal products
por: Patel, Dhavalkumar N., et al.
Publicado: (2015)

Comparative proteomic analysis of liver antioxidant mechanisms in Megalobrama amblycephala stimulated with dietary emodin
por: Song, Changyou, et al.
Publicado: (2017)

Inhibition of mechanical stress-induced hypertrophic scar inflammation by emodin
por: LIU, CHENG
Publicado: (2015)

Emodin Combined with Nanosilver Inhibited Sepsis by Anti-inflammatory Protection
por: Li, Hong, et al.
Publicado: (2017)

Emodin inhibits the proliferation of papillary thyroid carcinoma by activating AMPK
por: Li, Weilong, et al.
Publicado: (2021)

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity
por: Moles, Anna, et al.
Publicado: (2018)

Emodin affects ERCC1 expression in breast cancer cells
por: Fu, Jian-min, et al.
Publicado: (2012)

A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor
por: Lin, Longfei, et al.
Publicado: (2017)

Life without complex I: proteome analyses of an Arabidopsis mutant lacking the mitochondrial NADH dehydrogenase complex
por: Fromm, Steffanie, et al.
Publicado: (2016)

Simultaneous Estimation of Aloe Emodin and Emodin from Rheum emodi, Cassia alata and Aloes by HPTLC
por: Narayanan, Sindhu, et al.
Publicado: (2015)

Changes of the Cytoplasmic Proteome in Response to Alcoholic Hepatotoxicity in Rats
por: Kim, Dong Hwan, et al.
Publicado: (2015)

A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity
por: Xia, Wei, et al.
Publicado: (2021)

Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review
por: Lin, Longfei, et al.
Publicado: (2015)

Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells
por: Li, Jun, et al.
Publicado: (2018)

Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells
por: Park, Su Been, et al.
Publicado: (2023)

Bioinformatics combined with quantitative proteomics analyses and identification of potential biomarkers in cholangiocarcinoma
por: Da, Zijian, et al.
Publicado: (2020)

Bioconcentration and Metabolism of Emodin in Zebrafish Eleutheroembryos
por: Chen, Jiefeng, et al.
Publicado: (2017)

Selective emodin toxicity in cancer cells
por: Kolitsida, Panagiota, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tthnfrmf58hc8ql2ksatsjtfaq