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Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism
Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible factors (HIFs). The HIF target gene repertoire includes genes responsible for the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468845/ https://www.ncbi.nlm.nih.gov/pubmed/30832409 http://dx.doi.org/10.3390/cells8030214 |
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author | Mylonis, Ilias Simos, George Paraskeva, Efrosyni |
author_facet | Mylonis, Ilias Simos, George Paraskeva, Efrosyni |
author_sort | Mylonis, Ilias |
collection | PubMed |
description | Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible factors (HIFs). The HIF target gene repertoire includes genes responsible for the regulation of metabolism, oxygen delivery and cell survival. Although the involvement of HIFs in the regulation of carbohydrate metabolism and the switch to anaerobic glycolysis under hypoxia is well established, their role in the control of lipid anabolism and catabolism remains still relatively obscure. Recent evidence indicates that many aspects of lipid metabolism are modified during hypoxia or in tumor cells in a HIF-dependent manner, contributing significantly to the pathogenesis and/or progression of cancer and metabolic disorders. However, direct transcriptional regulation by HIFs has been only demonstrated in relatively few cases, leaving open the exact and isoform-specific mechanisms that underlie HIF-dependency. This review summarizes the evidence for both direct and indirect roles of HIFs in the regulation of genes involved in lipid metabolism as well as the involvement of HIFs in various diseases as demonstrated by studies with transgenic animal models. |
format | Online Article Text |
id | pubmed-6468845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64688452019-04-23 Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism Mylonis, Ilias Simos, George Paraskeva, Efrosyni Cells Review Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible factors (HIFs). The HIF target gene repertoire includes genes responsible for the regulation of metabolism, oxygen delivery and cell survival. Although the involvement of HIFs in the regulation of carbohydrate metabolism and the switch to anaerobic glycolysis under hypoxia is well established, their role in the control of lipid anabolism and catabolism remains still relatively obscure. Recent evidence indicates that many aspects of lipid metabolism are modified during hypoxia or in tumor cells in a HIF-dependent manner, contributing significantly to the pathogenesis and/or progression of cancer and metabolic disorders. However, direct transcriptional regulation by HIFs has been only demonstrated in relatively few cases, leaving open the exact and isoform-specific mechanisms that underlie HIF-dependency. This review summarizes the evidence for both direct and indirect roles of HIFs in the regulation of genes involved in lipid metabolism as well as the involvement of HIFs in various diseases as demonstrated by studies with transgenic animal models. MDPI 2019-03-03 /pmc/articles/PMC6468845/ /pubmed/30832409 http://dx.doi.org/10.3390/cells8030214 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mylonis, Ilias Simos, George Paraskeva, Efrosyni Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism |
title | Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism |
title_full | Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism |
title_fullStr | Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism |
title_full_unstemmed | Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism |
title_short | Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism |
title_sort | hypoxia-inducible factors and the regulation of lipid metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468845/ https://www.ncbi.nlm.nih.gov/pubmed/30832409 http://dx.doi.org/10.3390/cells8030214 |
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