Cargando…

Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair

Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of chronic kidney disease (CKD). Hypoxia, a conditi...

Descripción completa

Detalles Bibliográficos
Autores principales: Shu, Shaoqun, Wang, Ying, Zheng, Meiling, Liu, Zhiwen, Cai, Juan, Tang, Chengyuan, Dong, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468851/
https://www.ncbi.nlm.nih.gov/pubmed/30823476
http://dx.doi.org/10.3390/cells8030207
_version_ 1783411528710488064
author Shu, Shaoqun
Wang, Ying
Zheng, Meiling
Liu, Zhiwen
Cai, Juan
Tang, Chengyuan
Dong, Zheng
author_facet Shu, Shaoqun
Wang, Ying
Zheng, Meiling
Liu, Zhiwen
Cai, Juan
Tang, Chengyuan
Dong, Zheng
author_sort Shu, Shaoqun
collection PubMed
description Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of chronic kidney disease (CKD). Hypoxia, a condition of insufficient supply of oxygen to cells and tissues, occurs in both acute and chronic kidney diseases under a variety of clinical and experimental conditions. Hypoxia-inducible factors (HIFs) are the “master” transcription factors responsible for gene expression in hypoxia. Recent researches demonstrate that HIFs play an important role in kidney injury and repair by regulating HIF target genes, including microRNAs. However, there are controversies regarding the pathological roles of HIFs in kidney injury and repair. In this review, we describe the regulation, expression, and functions of HIFs, and their target genes and related functions. We also discuss the involvement of HIFs in AKI and kidney repair, presenting HIFs as effective therapeutic targets.
format Online
Article
Text
id pubmed-6468851
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64688512019-04-23 Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair Shu, Shaoqun Wang, Ying Zheng, Meiling Liu, Zhiwen Cai, Juan Tang, Chengyuan Dong, Zheng Cells Review Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of chronic kidney disease (CKD). Hypoxia, a condition of insufficient supply of oxygen to cells and tissues, occurs in both acute and chronic kidney diseases under a variety of clinical and experimental conditions. Hypoxia-inducible factors (HIFs) are the “master” transcription factors responsible for gene expression in hypoxia. Recent researches demonstrate that HIFs play an important role in kidney injury and repair by regulating HIF target genes, including microRNAs. However, there are controversies regarding the pathological roles of HIFs in kidney injury and repair. In this review, we describe the regulation, expression, and functions of HIFs, and their target genes and related functions. We also discuss the involvement of HIFs in AKI and kidney repair, presenting HIFs as effective therapeutic targets. MDPI 2019-02-28 /pmc/articles/PMC6468851/ /pubmed/30823476 http://dx.doi.org/10.3390/cells8030207 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shu, Shaoqun
Wang, Ying
Zheng, Meiling
Liu, Zhiwen
Cai, Juan
Tang, Chengyuan
Dong, Zheng
Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
title Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
title_full Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
title_fullStr Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
title_full_unstemmed Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
title_short Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
title_sort hypoxia and hypoxia-inducible factors in kidney injury and repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468851/
https://www.ncbi.nlm.nih.gov/pubmed/30823476
http://dx.doi.org/10.3390/cells8030207
work_keys_str_mv AT shushaoqun hypoxiaandhypoxiainduciblefactorsinkidneyinjuryandrepair
AT wangying hypoxiaandhypoxiainduciblefactorsinkidneyinjuryandrepair
AT zhengmeiling hypoxiaandhypoxiainduciblefactorsinkidneyinjuryandrepair
AT liuzhiwen hypoxiaandhypoxiainduciblefactorsinkidneyinjuryandrepair
AT caijuan hypoxiaandhypoxiainduciblefactorsinkidneyinjuryandrepair
AT tangchengyuan hypoxiaandhypoxiainduciblefactorsinkidneyinjuryandrepair
AT dongzheng hypoxiaandhypoxiainduciblefactorsinkidneyinjuryandrepair