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Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of chronic kidney disease (CKD). Hypoxia, a conditi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468851/ https://www.ncbi.nlm.nih.gov/pubmed/30823476 http://dx.doi.org/10.3390/cells8030207 |
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author | Shu, Shaoqun Wang, Ying Zheng, Meiling Liu, Zhiwen Cai, Juan Tang, Chengyuan Dong, Zheng |
author_facet | Shu, Shaoqun Wang, Ying Zheng, Meiling Liu, Zhiwen Cai, Juan Tang, Chengyuan Dong, Zheng |
author_sort | Shu, Shaoqun |
collection | PubMed |
description | Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of chronic kidney disease (CKD). Hypoxia, a condition of insufficient supply of oxygen to cells and tissues, occurs in both acute and chronic kidney diseases under a variety of clinical and experimental conditions. Hypoxia-inducible factors (HIFs) are the “master” transcription factors responsible for gene expression in hypoxia. Recent researches demonstrate that HIFs play an important role in kidney injury and repair by regulating HIF target genes, including microRNAs. However, there are controversies regarding the pathological roles of HIFs in kidney injury and repair. In this review, we describe the regulation, expression, and functions of HIFs, and their target genes and related functions. We also discuss the involvement of HIFs in AKI and kidney repair, presenting HIFs as effective therapeutic targets. |
format | Online Article Text |
id | pubmed-6468851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64688512019-04-23 Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair Shu, Shaoqun Wang, Ying Zheng, Meiling Liu, Zhiwen Cai, Juan Tang, Chengyuan Dong, Zheng Cells Review Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of chronic kidney disease (CKD). Hypoxia, a condition of insufficient supply of oxygen to cells and tissues, occurs in both acute and chronic kidney diseases under a variety of clinical and experimental conditions. Hypoxia-inducible factors (HIFs) are the “master” transcription factors responsible for gene expression in hypoxia. Recent researches demonstrate that HIFs play an important role in kidney injury and repair by regulating HIF target genes, including microRNAs. However, there are controversies regarding the pathological roles of HIFs in kidney injury and repair. In this review, we describe the regulation, expression, and functions of HIFs, and their target genes and related functions. We also discuss the involvement of HIFs in AKI and kidney repair, presenting HIFs as effective therapeutic targets. MDPI 2019-02-28 /pmc/articles/PMC6468851/ /pubmed/30823476 http://dx.doi.org/10.3390/cells8030207 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shu, Shaoqun Wang, Ying Zheng, Meiling Liu, Zhiwen Cai, Juan Tang, Chengyuan Dong, Zheng Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair |
title | Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair |
title_full | Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair |
title_fullStr | Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair |
title_full_unstemmed | Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair |
title_short | Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair |
title_sort | hypoxia and hypoxia-inducible factors in kidney injury and repair |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468851/ https://www.ncbi.nlm.nih.gov/pubmed/30823476 http://dx.doi.org/10.3390/cells8030207 |
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