Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics

Recent studies in cancer diagnostics have identified microRNAs (miRNAs) as promising cancer biomarkers. Single nucleotide polymorphisms (SNPs) in miRNA binding sites, seed regions, and coding sequences can help predict breast cancer risk, aggressiveness, response to stimuli, and prognosis. This revi...

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Detalles Bibliográficos
Autores principales: Malhotra, Poonam, Read, Graham H., Weidhaas, Joanne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468861/
https://www.ncbi.nlm.nih.gov/pubmed/30897768
http://dx.doi.org/10.3390/ncrna5010027
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author Malhotra, Poonam
Read, Graham H.
Weidhaas, Joanne B.
author_facet Malhotra, Poonam
Read, Graham H.
Weidhaas, Joanne B.
author_sort Malhotra, Poonam
collection PubMed
description Recent studies in cancer diagnostics have identified microRNAs (miRNAs) as promising cancer biomarkers. Single nucleotide polymorphisms (SNPs) in miRNA binding sites, seed regions, and coding sequences can help predict breast cancer risk, aggressiveness, response to stimuli, and prognosis. This review also documents significant known miR-SNPs in miRNA biogenesis genes and their effects on gene regulation in breast cancer, taking into account the genetic background and ethnicity of the sampled populations. When applicable, miR-SNPs are evaluated in the context of other patient factors, including mutations, hormonal status, and demographics. Given the power of miR-SNPs to predict patient cancer risk, prognosis, and outcomes, further study of miR-SNPs is warranted to improve efforts towards personalized medicine.
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spelling pubmed-64688612019-04-19 Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics Malhotra, Poonam Read, Graham H. Weidhaas, Joanne B. Noncoding RNA Review Recent studies in cancer diagnostics have identified microRNAs (miRNAs) as promising cancer biomarkers. Single nucleotide polymorphisms (SNPs) in miRNA binding sites, seed regions, and coding sequences can help predict breast cancer risk, aggressiveness, response to stimuli, and prognosis. This review also documents significant known miR-SNPs in miRNA biogenesis genes and their effects on gene regulation in breast cancer, taking into account the genetic background and ethnicity of the sampled populations. When applicable, miR-SNPs are evaluated in the context of other patient factors, including mutations, hormonal status, and demographics. Given the power of miR-SNPs to predict patient cancer risk, prognosis, and outcomes, further study of miR-SNPs is warranted to improve efforts towards personalized medicine. MDPI 2019-03-20 /pmc/articles/PMC6468861/ /pubmed/30897768 http://dx.doi.org/10.3390/ncrna5010027 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malhotra, Poonam
Read, Graham H.
Weidhaas, Joanne B.
Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics
title Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics
title_full Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics
title_fullStr Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics
title_full_unstemmed Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics
title_short Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics
title_sort breast cancer and mir-snps: the importance of mir germ-line genetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468861/
https://www.ncbi.nlm.nih.gov/pubmed/30897768
http://dx.doi.org/10.3390/ncrna5010027
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