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Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches

Mitochondria harbor their own genetic system, yet critically depend on the import of a number of nuclear-encoded macromolecules to ensure their expression. In all eukaryotes, selected non-coding RNAs produced from the nuclear genome are partially redirected into the mitochondria, where they particip...

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Autores principales: Jeandard, Damien, Smirnova, Anna, Tarassov, Ivan, Barrey, Eric, Smirnov, Alexandre, Entelis, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468882/
https://www.ncbi.nlm.nih.gov/pubmed/30917553
http://dx.doi.org/10.3390/cells8030286
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author Jeandard, Damien
Smirnova, Anna
Tarassov, Ivan
Barrey, Eric
Smirnov, Alexandre
Entelis, Nina
author_facet Jeandard, Damien
Smirnova, Anna
Tarassov, Ivan
Barrey, Eric
Smirnov, Alexandre
Entelis, Nina
author_sort Jeandard, Damien
collection PubMed
description Mitochondria harbor their own genetic system, yet critically depend on the import of a number of nuclear-encoded macromolecules to ensure their expression. In all eukaryotes, selected non-coding RNAs produced from the nuclear genome are partially redirected into the mitochondria, where they participate in gene expression. Therefore, the mitochondrial RNome represents an intricate mixture of the intrinsic transcriptome and the extrinsic RNA importome. In this review, we summarize and critically analyze data on the nuclear-encoded transcripts detected in human mitochondria and outline the proposed molecular mechanisms of their mitochondrial import. Special attention is given to the various experimental approaches used to study the mitochondrial RNome, including some recently developed genome-wide and in situ techniques.
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spelling pubmed-64688822019-04-23 Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches Jeandard, Damien Smirnova, Anna Tarassov, Ivan Barrey, Eric Smirnov, Alexandre Entelis, Nina Cells Review Mitochondria harbor their own genetic system, yet critically depend on the import of a number of nuclear-encoded macromolecules to ensure their expression. In all eukaryotes, selected non-coding RNAs produced from the nuclear genome are partially redirected into the mitochondria, where they participate in gene expression. Therefore, the mitochondrial RNome represents an intricate mixture of the intrinsic transcriptome and the extrinsic RNA importome. In this review, we summarize and critically analyze data on the nuclear-encoded transcripts detected in human mitochondria and outline the proposed molecular mechanisms of their mitochondrial import. Special attention is given to the various experimental approaches used to study the mitochondrial RNome, including some recently developed genome-wide and in situ techniques. MDPI 2019-03-26 /pmc/articles/PMC6468882/ /pubmed/30917553 http://dx.doi.org/10.3390/cells8030286 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jeandard, Damien
Smirnova, Anna
Tarassov, Ivan
Barrey, Eric
Smirnov, Alexandre
Entelis, Nina
Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
title Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
title_full Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
title_fullStr Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
title_full_unstemmed Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
title_short Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
title_sort import of non-coding rnas into human mitochondria: a critical review and emerging approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468882/
https://www.ncbi.nlm.nih.gov/pubmed/30917553
http://dx.doi.org/10.3390/cells8030286
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