The Role of MicroRNAs in Hepatoblastoma Tumors

Hepatoblastoma is the most common hepatic malignancy during childhood. However, little is still known about the molecular mechanisms that govern the development of this disease. This review is focused on the recent advances regarding the study of microRNAs in hepatoblastoma and their substantial con...

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Autores principales: Cristóbal, Ion, Sanz-Álvarez, Marta, Luque, Melani, Caramés, Cristina, Rojo, Federico, García-Foncillas, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468899/
https://www.ncbi.nlm.nih.gov/pubmed/30909459
http://dx.doi.org/10.3390/cancers11030409
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author Cristóbal, Ion
Sanz-Álvarez, Marta
Luque, Melani
Caramés, Cristina
Rojo, Federico
García-Foncillas, Jesús
author_facet Cristóbal, Ion
Sanz-Álvarez, Marta
Luque, Melani
Caramés, Cristina
Rojo, Federico
García-Foncillas, Jesús
author_sort Cristóbal, Ion
collection PubMed
description Hepatoblastoma is the most common hepatic malignancy during childhood. However, little is still known about the molecular mechanisms that govern the development of this disease. This review is focused on the recent advances regarding the study of microRNAs in hepatoblastoma and their substantial contribution to improv our knowledge of the pathogenesis of this disease. We show here that miRNAs represent valuable tools to identify signaling pathways involved in hepatoblastoma progression as well as useful biomarkers and novel molecular targets to develop alternative therapeutic strategies in this disease.
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spelling pubmed-64688992019-04-23 The Role of MicroRNAs in Hepatoblastoma Tumors Cristóbal, Ion Sanz-Álvarez, Marta Luque, Melani Caramés, Cristina Rojo, Federico García-Foncillas, Jesús Cancers (Basel) Review Hepatoblastoma is the most common hepatic malignancy during childhood. However, little is still known about the molecular mechanisms that govern the development of this disease. This review is focused on the recent advances regarding the study of microRNAs in hepatoblastoma and their substantial contribution to improv our knowledge of the pathogenesis of this disease. We show here that miRNAs represent valuable tools to identify signaling pathways involved in hepatoblastoma progression as well as useful biomarkers and novel molecular targets to develop alternative therapeutic strategies in this disease. MDPI 2019-03-22 /pmc/articles/PMC6468899/ /pubmed/30909459 http://dx.doi.org/10.3390/cancers11030409 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cristóbal, Ion
Sanz-Álvarez, Marta
Luque, Melani
Caramés, Cristina
Rojo, Federico
García-Foncillas, Jesús
The Role of MicroRNAs in Hepatoblastoma Tumors
title The Role of MicroRNAs in Hepatoblastoma Tumors
title_full The Role of MicroRNAs in Hepatoblastoma Tumors
title_fullStr The Role of MicroRNAs in Hepatoblastoma Tumors
title_full_unstemmed The Role of MicroRNAs in Hepatoblastoma Tumors
title_short The Role of MicroRNAs in Hepatoblastoma Tumors
title_sort role of micrornas in hepatoblastoma tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468899/
https://www.ncbi.nlm.nih.gov/pubmed/30909459
http://dx.doi.org/10.3390/cancers11030409
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