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Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy

Histone DeACetylases (HDACs) are enzymes that remove acetyl groups from histones and other proteins, regulating the expression of target genes. Pharmacological inhibition of these enzymes re-shapes chromatin acetylation status, confusing boundaries between transcriptionally active and quiescent chro...

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Detalles Bibliográficos
Autores principales:	Manzotti, Gloria, Ciarrocchi, Alessia, Sancisi, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468908/ https://www.ncbi.nlm.nih.gov/pubmed/30841549 http://dx.doi.org/10.3390/cancers11030304

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