Cargando…

Silenced PITX1 promotes chemotherapeutic resistance to 5-fluorocytosine and cisplatin in gastric cancer cells

Resistance to chemotherapeutic drugs leads to a poor prognosis in gastric cancer (GC). The present study aimed to assess the association between pituitary homeobox paired homeodomain transcription 1 (PITX1) expression and the sensitivity of GC cells to the chemotherapeutic drugs 5-fluorouracil (5-FU...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Xiaohui, Gu, Yuejun, Yu, Shengling, Gong, Pihai, Mao, Yuhang, Li, Yiping, Zheng, Ying, Qiao, Fengchang, Zhao, Zhujiang, Fan, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468935/ https://www.ncbi.nlm.nih.gov/pubmed/31007741 http://dx.doi.org/10.3892/etm.2019.7459

Ejemplares similares

DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer
por: Cui, He, et al.
Publicado: (2018)

LncRNA UCA1 promotes tumor metastasis by inducing miR-203/ZEB2 axis in gastric cancer
por: Gong, Pihai, et al.
Publicado: (2018)

Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells
por: Gong, Pihai, et al.
Publicado: (2021)

[Corrigendum] Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells
por: Gong, Pihai, et al.
Publicado: (2023)

Deregulation between miR-29b/c and DNMT3A Is Associated with Epigenetic Silencing of the CDH1 Gene, Affecting Cell Migration and Invasion in Gastric Cancer
por: Cui, He, et al.
Publicado: (2015)

A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity
por: Wu, Huazhang, et al.
Publicado: (2014)

Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
por: Delma, Fatima Zohra, et al.
Publicado: (2021)

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
por: Billmyre, R. Blake, et al.
Publicado: (2020)

Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs
por: Béguin, Jérémy, et al.
Publicado: (2021)

Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor
por: Hwang, Yawon, et al.
Publicado: (2017)

Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
por: Chang, Yun C., et al.
Publicado: (2021)

Reduced miR-29a-3p expression is linked to the cell proliferation and cell migration in gastric cancer
por: Zhao, Zhujiang, et al.
Publicado: (2015)

A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma
por: Fan, Hong, et al.
Publicado: (2010)

Hydrogen-bonding patterns in 5-fluorocytosine–melamine co-crystal (4/1)
por: Mohana, Marimuthu, et al.
Publicado: (2016)

Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers
por: Ding, Yuedi, et al.
Publicado: (2020)

DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18(INK4C) in gastric carcinogenesis
por: Cui, He, et al.
Publicado: (2015)

Targeted antitumor prodrug therapy using CNGRC-yCD fusion protein in combination with 5-fluorocytosine
por: Li, Jia-Je, et al.
Publicado: (2016)

DNA hypermethyation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma
por: Otsubo, Takeshi, et al.
Publicado: (2017)

Pitx2 in Embryonic and Adult Myogenesis
por: Hernandez-Torres, Francisco, et al.
Publicado: (2017)

Non-invasive (19)F MR spectroscopy of 5-fluorocytosine to 5-fluorouracil conversion by recombinant Salmonella in tumours
por: Dresselaers, T, et al.
Publicado: (2003)

Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE
por: Kang, Jianping, et al.
Publicado: (2022)

The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment
por: Sastré-Velásquez, Luis Enrique, et al.
Publicado: (2022)

Oncolytic virotherapy with intratumoral injection of vaccinia virus TG6002 and 5-fluorocytosine administration in dogs with malignant tumors
por: Béguin, Jérémy, et al.
Publicado: (2023)

Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer
por: Zhang, Yan, et al.
Publicado: (2020)

Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin
por: García-Rodríguez, Francisco Javier, et al.
Publicado: (2018)

LncRNA TRERNA1 Function as an Enhancer of SNAI1 Promotes Gastric Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition
por: Wu, Huazhang, et al.
Publicado: (2017)

Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives
por: El Mansouri, Az-eddine, et al.
Publicado: (2022)

PITX1 plays essential functions in cancer
por: Zhao, Jingpu, et al.
Publicado: (2023)

A novel method to generate unmarked gene deletions in the intracellular pathogen Rhodococcus equi using 5-fluorocytosine conditional lethality
por: van der Geize, R., et al.
Publicado: (2008)

Safety and Efficacy of Suicide Gene Therapy with Adenosine Deaminase 5-Fluorocytosine Silmutaneously in in Vitro Cultures of Melanoma and Retinal Cell Lines
por: Sakkas, Antonios, et al.
Publicado: (2014)

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model
por: Mitchell, Leah A., et al.
Publicado: (2017)

Overexpression of xeroderma pigmentosum group C decreases the chemotherapeutic sensitivity of colorectal carcinoma cells to cisplatin
por: Zhang, Yi, et al.
Publicado: (2018)

Silencing IGFBP-2 decreases pancreatic cancer metastasis and enhances chemotherapeutic sensitivity
por: Liu, Huan, et al.
Publicado: (2017)

Transgenic Insights Linking Pitx2 and Atrial Arrhythmias
por: Franco, Diego, et al.
Publicado: (2012)

Multiple Roles of Pitx2 in Cardiac Development and Disease
por: Franco, Diego, et al.
Publicado: (2017)

A PITX2 splice-site mutation in a family with Axenfeld-Rieger syndrome leads to decreased expression of nuclear PITX2 protein
por: Zhang, Feng, et al.
Publicado: (2021)

Co-Administration of Fendiline Hydrochloride Enhances Chemotherapeutic Efficacy of Cisplatin in Neuroblastoma Treatment
por: Brizzolara, Antonella, et al.
Publicado: (2020)

Amphotericin B plus fluorocytosine combined with voriconazole for the treatment of non-HIV and non-transplant-associated cryptococcal meningitis: a retrospective study
por: Liu, Junyu, et al.
Publicado: (2022)

Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells
por: Tanaka, Mamoru, et al.
Publicado: (2013)

PITX2C loss-of-function mutations responsible for idiopathic atrial fibrillation
por: Qiu, Xing-Biao, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_odhab0ski33mfo7q1ui0c0gfmu