Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)

In article 1801531, Rong Fan and co‐workers examine the dynamics of brain tumor cells in a microvasculature‐on‐a‐chip system. Tumor cells residing in the perivascular zone show various degrees of co‐localization with microvessels across ten glioblastoma patients. Single‐cell transcriptome sequencing...

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Detalles Bibliográficos
Autores principales: Xiao, Yang, Kim, Dongjoo, Dura, Burak, Zhang, Kerou, Yan, Runchen, Li, Huamin, Han, Edward, Ip, Joshua, Zou, Pan, Liu, Jun, Chen, Ann Tai, Vortmeyer, Alexander O., Zhou, Jiangbing, Fan, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468959/
http://dx.doi.org/10.1002/advs.201970046
Descripción
Sumario:In article 1801531, Rong Fan and co‐workers examine the dynamics of brain tumor cells in a microvasculature‐on‐a‐chip system. Tumor cells residing in the perivascular zone show various degrees of co‐localization with microvessels across ten glioblastoma patients. Single‐cell transcriptome sequencing (21 750 single cells) reveals that brain tumor cells with high expression of PDGFRA preferentially localize in the perivascular niche. [Image: see text]

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