Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)

In article 1801531, Rong Fan and co‐workers examine the dynamics of brain tumor cells in a microvasculature‐on‐a‐chip system. Tumor cells residing in the perivascular zone show various degrees of co‐localization with microvessels across ten glioblastoma patients. Single‐cell transcriptome sequencing...

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Detalles Bibliográficos
Autores principales: Xiao, Yang, Kim, Dongjoo, Dura, Burak, Zhang, Kerou, Yan, Runchen, Li, Huamin, Han, Edward, Ip, Joshua, Zou, Pan, Liu, Jun, Chen, Ann Tai, Vortmeyer, Alexander O., Zhou, Jiangbing, Fan, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468959/
http://dx.doi.org/10.1002/advs.201970046
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author Xiao, Yang
Kim, Dongjoo
Dura, Burak
Zhang, Kerou
Yan, Runchen
Li, Huamin
Han, Edward
Ip, Joshua
Zou, Pan
Liu, Jun
Chen, Ann Tai
Vortmeyer, Alexander O.
Zhou, Jiangbing
Fan, Rong
author_facet Xiao, Yang
Kim, Dongjoo
Dura, Burak
Zhang, Kerou
Yan, Runchen
Li, Huamin
Han, Edward
Ip, Joshua
Zou, Pan
Liu, Jun
Chen, Ann Tai
Vortmeyer, Alexander O.
Zhou, Jiangbing
Fan, Rong
author_sort Xiao, Yang
collection PubMed
description In article 1801531, Rong Fan and co‐workers examine the dynamics of brain tumor cells in a microvasculature‐on‐a‐chip system. Tumor cells residing in the perivascular zone show various degrees of co‐localization with microvessels across ten glioblastoma patients. Single‐cell transcriptome sequencing (21 750 single cells) reveals that brain tumor cells with high expression of PDGFRA preferentially localize in the perivascular niche. [Image: see text]
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spelling pubmed-64689592019-04-23 Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019) Xiao, Yang Kim, Dongjoo Dura, Burak Zhang, Kerou Yan, Runchen Li, Huamin Han, Edward Ip, Joshua Zou, Pan Liu, Jun Chen, Ann Tai Vortmeyer, Alexander O. Zhou, Jiangbing Fan, Rong Adv Sci (Weinh) Inside Front Cover In article 1801531, Rong Fan and co‐workers examine the dynamics of brain tumor cells in a microvasculature‐on‐a‐chip system. Tumor cells residing in the perivascular zone show various degrees of co‐localization with microvessels across ten glioblastoma patients. Single‐cell transcriptome sequencing (21 750 single cells) reveals that brain tumor cells with high expression of PDGFRA preferentially localize in the perivascular niche. [Image: see text] John Wiley and Sons Inc. 2019-04-17 /pmc/articles/PMC6468959/ http://dx.doi.org/10.1002/advs.201970046 Text en © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Inside Front Cover
Xiao, Yang
Kim, Dongjoo
Dura, Burak
Zhang, Kerou
Yan, Runchen
Li, Huamin
Han, Edward
Ip, Joshua
Zou, Pan
Liu, Jun
Chen, Ann Tai
Vortmeyer, Alexander O.
Zhou, Jiangbing
Fan, Rong
Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
title Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
title_full Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
title_fullStr Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
title_full_unstemmed Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
title_short Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
title_sort organ‐on‐a‐chip: ex vivo dynamics of human glioblastoma cells in a microvasculature‐on‐a‐chip system correlates with tumor heterogeneity and subtypes (adv. sci. 8/2019)
topic Inside Front Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468959/
http://dx.doi.org/10.1002/advs.201970046
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