Cargando…

Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease

The lungs are essential for gas exchange and serve as the gateways of our body to the external environment. They are easily accessible for drugs from both sides, the airways and the vasculature. Recent literature provides evidence for a role of Transient Receptor Potential (TRP) channels as chemosen...

Descripción completa

Detalles Bibliográficos
Autor principal: Dietrich, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469169/
https://www.ncbi.nlm.nih.gov/pubmed/30717260
http://dx.doi.org/10.3390/ph12010023
_version_ 1783411591642873856
author Dietrich, Alexander
author_facet Dietrich, Alexander
author_sort Dietrich, Alexander
collection PubMed
description The lungs are essential for gas exchange and serve as the gateways of our body to the external environment. They are easily accessible for drugs from both sides, the airways and the vasculature. Recent literature provides evidence for a role of Transient Receptor Potential (TRP) channels as chemosensors and essential members of signal transduction cascades in stress-induced cellular responses. This review will focus on TRP channels (TRPA1, TRPC6, TRPV1, and TRPV4), predominantly expressed in non-neuronal lung tissues and their involvement in pathways associated with diseases like asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD), lung fibrosis, and edema formation. Recently identified specific modulators of these channels and their potential as new therapeutic options as well as strategies for a causal treatment based on the mechanistic understanding of molecular events will also be evaluated.
format Online
Article
Text
id pubmed-6469169
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64691692019-04-24 Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease Dietrich, Alexander Pharmaceuticals (Basel) Review The lungs are essential for gas exchange and serve as the gateways of our body to the external environment. They are easily accessible for drugs from both sides, the airways and the vasculature. Recent literature provides evidence for a role of Transient Receptor Potential (TRP) channels as chemosensors and essential members of signal transduction cascades in stress-induced cellular responses. This review will focus on TRP channels (TRPA1, TRPC6, TRPV1, and TRPV4), predominantly expressed in non-neuronal lung tissues and their involvement in pathways associated with diseases like asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD), lung fibrosis, and edema formation. Recently identified specific modulators of these channels and their potential as new therapeutic options as well as strategies for a causal treatment based on the mechanistic understanding of molecular events will also be evaluated. MDPI 2019-02-01 /pmc/articles/PMC6469169/ /pubmed/30717260 http://dx.doi.org/10.3390/ph12010023 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dietrich, Alexander
Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease
title Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease
title_full Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease
title_fullStr Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease
title_full_unstemmed Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease
title_short Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease
title_sort modulators of transient receptor potential (trp) channels as therapeutic options in lung disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469169/
https://www.ncbi.nlm.nih.gov/pubmed/30717260
http://dx.doi.org/10.3390/ph12010023
work_keys_str_mv AT dietrichalexander modulatorsoftransientreceptorpotentialtrpchannelsastherapeuticoptionsinlungdisease