Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression

Juvenile idiopathic arthritis (JIA) represents joint inflammation with an unknown cause that starts before the age of 16, resulting in stiff and painful joints. In addition, JIA patients often report symptoms of sickness behavior. Recent animal studies suggest that proinflammatory cytokines produce...

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Detalles Bibliográficos
Autores principales: Korte-Bouws, Gerdien A. H., Albers, Eline, Voskamp, Marije, Hendriksen, Hendrikus, de Leeuw, Lidewij R., Güntürkün, Onur, de Roock, Sytze, Vastert, Sebastiaan J., Korte, S. Mechiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469185/
https://www.ncbi.nlm.nih.gov/pubmed/30625990
http://dx.doi.org/10.3390/ph12010009

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