Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation

BACKGROUND: Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silen...

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Detalles Bibliográficos
Autores principales: Chu, Duan, Wei, Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469204/
https://www.ncbi.nlm.nih.gov/pubmed/30991970
http://dx.doi.org/10.1186/s12885-019-5572-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469204/
https://www.ncbi.nlm.nih.gov/pubmed/30991970
http://dx.doi.org/10.1186/s12885-019-5572-x

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