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Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells

We recently described an unconventional mode of gene regulation in budding yeast by which transcriptional and translational interference collaborate to down-regulate protein expression. Developmentally timed transcriptional interference inhibited production of a well translated mRNA isoform and resu...

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Detalles Bibliográficos
Autores principales:	Hollerer, Ina, Barker, Juliet C., Jorgensen, Victoria, Tresenrider, Amy, Dugast-Darzacq, Claire, Chan, Leon Y., Darzacq, Xavier, Tjian, Robert, Ünal, Elçin, Brar, Gloria A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2019
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469420/ https://www.ncbi.nlm.nih.gov/pubmed/30723103 http://dx.doi.org/10.1534/g3.118.200802

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