Signaling by adenosine receptors—Homeostatic or allostatic control?

Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overal...

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Detalles Bibliográficos
Autor principal: Cunha, Rodrigo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469789/
https://www.ncbi.nlm.nih.gov/pubmed/30951527
http://dx.doi.org/10.1371/journal.pbio.3000213
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author Cunha, Rodrigo A.
author_facet Cunha, Rodrigo A.
author_sort Cunha, Rodrigo A.
collection PubMed
description Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed “normal” physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis.
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spelling pubmed-64697892019-05-03 Signaling by adenosine receptors—Homeostatic or allostatic control? Cunha, Rodrigo A. PLoS Biol Primer Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed “normal” physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis. Public Library of Science 2019-04-05 /pmc/articles/PMC6469789/ /pubmed/30951527 http://dx.doi.org/10.1371/journal.pbio.3000213 Text en © 2019 Rodrigo A. Cunha http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Cunha, Rodrigo A.
Signaling by adenosine receptors—Homeostatic or allostatic control?
title Signaling by adenosine receptors—Homeostatic or allostatic control?
title_full Signaling by adenosine receptors—Homeostatic or allostatic control?
title_fullStr Signaling by adenosine receptors—Homeostatic or allostatic control?
title_full_unstemmed Signaling by adenosine receptors—Homeostatic or allostatic control?
title_short Signaling by adenosine receptors—Homeostatic or allostatic control?
title_sort signaling by adenosine receptors—homeostatic or allostatic control?
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469789/
https://www.ncbi.nlm.nih.gov/pubmed/30951527
http://dx.doi.org/10.1371/journal.pbio.3000213
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