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A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned

The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of fundus autofluorescence imaging, optical coherence tomography, and microperimetry. The overarching objectives of the studies were to document...

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Autores principales: Ervin, Ann-Margret, Strauss, Rupert W., Ahmed, Mohamed I., Birch, David, Cheetham, Janet, Ferris, Frederick L., Ip, Michael S., Jaffe, Glenn J., Maguire, Maureen G., Schönbach, Etienne M., Sadda, SriniVas R., West, Sheila K., Scholl, Hendrik P.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469878/
https://www.ncbi.nlm.nih.gov/pubmed/31019847
http://dx.doi.org/10.1167/tvst.8.2.16
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author Ervin, Ann-Margret
Strauss, Rupert W.
Ahmed, Mohamed I.
Birch, David
Cheetham, Janet
Ferris, Frederick L.
Ip, Michael S.
Jaffe, Glenn J.
Maguire, Maureen G.
Schönbach, Etienne M.
Sadda, SriniVas R.
West, Sheila K.
Scholl, Hendrik P.N.
author_facet Ervin, Ann-Margret
Strauss, Rupert W.
Ahmed, Mohamed I.
Birch, David
Cheetham, Janet
Ferris, Frederick L.
Ip, Michael S.
Jaffe, Glenn J.
Maguire, Maureen G.
Schönbach, Etienne M.
Sadda, SriniVas R.
West, Sheila K.
Scholl, Hendrik P.N.
author_sort Ervin, Ann-Margret
collection PubMed
description The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of fundus autofluorescence imaging, optical coherence tomography, and microperimetry. The overarching objectives of the studies were to document the natural course of Stargardt disease and identify the most appropriate clinical outcome measures for clinical trials assessing the efficacy and safety of upcoming treatments for Stargardt disease. A workshop organized by the Foundation Fighting Blindness Clinical Research Institute was held on June 11, 2018, in Baltimore, MD, USA. Invited speakers discussed spectral-domain optical coherence tomography, fundus autofluorescence, and microperimetry methods and findings in the ProgStar prospective study. The workshop concluded with a panel discussion of optimal endpoints for measuring treatment efficacy in Stargardt disease. We summarize the workshop presentations in light of the most current literature on Stargardt disease and discuss potential clinical outcome measures and endpoints for future treatment trials.
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spelling pubmed-64698782019-04-24 A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned Ervin, Ann-Margret Strauss, Rupert W. Ahmed, Mohamed I. Birch, David Cheetham, Janet Ferris, Frederick L. Ip, Michael S. Jaffe, Glenn J. Maguire, Maureen G. Schönbach, Etienne M. Sadda, SriniVas R. West, Sheila K. Scholl, Hendrik P.N. Transl Vis Sci Technol New Developments in Vision Research The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of fundus autofluorescence imaging, optical coherence tomography, and microperimetry. The overarching objectives of the studies were to document the natural course of Stargardt disease and identify the most appropriate clinical outcome measures for clinical trials assessing the efficacy and safety of upcoming treatments for Stargardt disease. A workshop organized by the Foundation Fighting Blindness Clinical Research Institute was held on June 11, 2018, in Baltimore, MD, USA. Invited speakers discussed spectral-domain optical coherence tomography, fundus autofluorescence, and microperimetry methods and findings in the ProgStar prospective study. The workshop concluded with a panel discussion of optimal endpoints for measuring treatment efficacy in Stargardt disease. We summarize the workshop presentations in light of the most current literature on Stargardt disease and discuss potential clinical outcome measures and endpoints for future treatment trials. The Association for Research in Vision and Ophthalmology 2019-04-12 /pmc/articles/PMC6469878/ /pubmed/31019847 http://dx.doi.org/10.1167/tvst.8.2.16 Text en Copyright 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle New Developments in Vision Research
Ervin, Ann-Margret
Strauss, Rupert W.
Ahmed, Mohamed I.
Birch, David
Cheetham, Janet
Ferris, Frederick L.
Ip, Michael S.
Jaffe, Glenn J.
Maguire, Maureen G.
Schönbach, Etienne M.
Sadda, SriniVas R.
West, Sheila K.
Scholl, Hendrik P.N.
A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned
title A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned
title_full A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned
title_fullStr A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned
title_full_unstemmed A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned
title_short A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned
title_sort workshop on measuring the progression of atrophy secondary to stargardt disease in the progstar studies: findings and lessons learned
topic New Developments in Vision Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469878/
https://www.ncbi.nlm.nih.gov/pubmed/31019847
http://dx.doi.org/10.1167/tvst.8.2.16
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