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Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information
Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469968/ https://www.ncbi.nlm.nih.gov/pubmed/30992350 http://dx.doi.org/10.1128/mBio.00431-19 |
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author | Cobián Güemes, Ana Georgina Lim, Yan Wei Quinn, Robert A. Conrad, Douglas J. Benler, Sean Maughan, Heather Edwards, Rob Brettin, Thomas Cantú, Vito Adrian Cuevas, Daniel Hamidi, Rohaum Dorrestein, Pieter Rohwer, Forest |
author_facet | Cobián Güemes, Ana Georgina Lim, Yan Wei Quinn, Robert A. Conrad, Douglas J. Benler, Sean Maughan, Heather Edwards, Rob Brettin, Thomas Cantú, Vito Adrian Cuevas, Daniel Hamidi, Rohaum Dorrestein, Pieter Rohwer, Forest |
author_sort | Cobián Güemes, Ana Georgina |
collection | PubMed |
description | Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of the viral and microbial community during acute CF exacerbations. To highlight CFRR, a case study of a CF patient is presented, in which an abrupt decline in lung function characterized a fatal exacerbation. The microbial community in the patient’s lungs was closely monitored through the multi-omics strategy, which led to the identification of pathogenic shigatoxigenic Escherichia coli (STEC) expressing Shiga toxin. This case study illustrates the potential for the CFRR to deconstruct complicated disease dynamics and provide clinicians with alternative treatments to improve the outcomes of pulmonary exacerbations and expand the life spans of individuals with CF. |
format | Online Article Text |
id | pubmed-6469968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-64699682019-04-24 Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information Cobián Güemes, Ana Georgina Lim, Yan Wei Quinn, Robert A. Conrad, Douglas J. Benler, Sean Maughan, Heather Edwards, Rob Brettin, Thomas Cantú, Vito Adrian Cuevas, Daniel Hamidi, Rohaum Dorrestein, Pieter Rohwer, Forest mBio Research Article Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of the viral and microbial community during acute CF exacerbations. To highlight CFRR, a case study of a CF patient is presented, in which an abrupt decline in lung function characterized a fatal exacerbation. The microbial community in the patient’s lungs was closely monitored through the multi-omics strategy, which led to the identification of pathogenic shigatoxigenic Escherichia coli (STEC) expressing Shiga toxin. This case study illustrates the potential for the CFRR to deconstruct complicated disease dynamics and provide clinicians with alternative treatments to improve the outcomes of pulmonary exacerbations and expand the life spans of individuals with CF. American Society for Microbiology 2019-04-16 /pmc/articles/PMC6469968/ /pubmed/30992350 http://dx.doi.org/10.1128/mBio.00431-19 Text en Copyright © 2019 Cobián Güemes et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Cobián Güemes, Ana Georgina Lim, Yan Wei Quinn, Robert A. Conrad, Douglas J. Benler, Sean Maughan, Heather Edwards, Rob Brettin, Thomas Cantú, Vito Adrian Cuevas, Daniel Hamidi, Rohaum Dorrestein, Pieter Rohwer, Forest Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information |
title | Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information |
title_full | Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information |
title_fullStr | Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information |
title_full_unstemmed | Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information |
title_short | Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information |
title_sort | cystic fibrosis rapid response: translating multi-omics data into clinically relevant information |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469968/ https://www.ncbi.nlm.nih.gov/pubmed/30992350 http://dx.doi.org/10.1128/mBio.00431-19 |
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